Predictors of disease flare after discontinuation of concomitant methotrexate in Japanese patients with rheumatoid arthritis treated with tocilizumab.

Joint, Bone, Spine : Revue Du Rhumatisme
Shuji AsaiToshihisa Kojima

Abstract

To investigate predictors of disease flare after methotrexate discontinuation in Japanese rheumatoid arthritis (RA) patients with sustained low disease activity undergoing tocilizumab plus methotrexate combination therapy. Participants of this multicenter, open-label, uncontrolled, prospective study were RA patients maintaining low disease activity (Clinical Disease Activity Index [CDAI]≤10) for≥12weeks with tocilizumab plus methotrexate. Methotrexate was discontinued after 12weeks of biweekly administration while continuing tocilizumab therapy. Disease flare was defined as either a CDAI score>10 or intervention with rescue treatments for any reason even if the CDAI score was≤10. The impact of baseline characteristics on disease flare at week 64 (52weeks after methotrexate discontinuation) was assessed with logistic regression models. Efficacy analyses were performed in 49 patients, of whom 15 had a disease flare by week 64. The proportion (95% confidence interval [CI]) of patients who maintained low disease activity without a flare at week 64 was 69.4% (54.6-81.8%). The dosing interval of tocilizumab was longer than that described on the drug label in Japan (i.e., intravenously every 4weeks, or subcutaneously every 2weeks) in ...Continue Reading

References

Mar 6, 2004·Lancet·Lars KlareskogUNKNOWN TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study investigators
Nov 27, 2004·Journal of Gastroenterology·Motoyasu KusanoMasatomo Mori
Jun 28, 2014·TheScientificWorldJournal·Rajalingham SakthiswaryBernard Yu Hor Thong
Nov 8, 2015·Arthritis Care & Research·Jasvinder A SinghTimothy McAlindon
Mar 17, 2017·The Journal of Rheumatology·Shuntaro SaitoTsutomu Takeuchi
Jan 27, 2018·Clinical Reviews in Allergy & Immunology·Ennio Giulio FavalliPier Luigi Meroni
Sep 1, 2018·International Journal of Rheumatic Diseases·Shuji AsaiToshihisa Kojima

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