Predictors of disengagement from treatment in an early psychosis program

Schizophrenia Research
Jacqueline StowkowyJean Addington

Abstract

Disengagement from treatment is a major concern in psychiatry. This is of particular concern for those presenting for care at their first episode of psychosis (FEP). The purpose of this study is to determine the rate of disengagement from a three year FE treatment program and the predictors of disengagement. We used a longitudinal cohort design. The cohort consisted of 286 FEP individuals. Measures included assessments of positive and negative symptoms, depression, substance use, premorbid and current functioning, cognition and duration of untreated psychosis. Disengagement from treatment was defined as leaving the program before the 30 months. At 30 months after treatment, the estimated rate of disengagement from treatment was 31%. Predictors of disengagement were examined via Cox proportional hazards models which revealed that lower ratings on negative symptom scores at baseline (HR=0.946; CI=0.909-0.985), a shorter duration of untreated psychosis (HR=0.997; CI=0.994-0.999), and not having a family member involved in the program (HR=0.310; CI=0.196-0.490) contributed significantly to predicting disengagement from treatment. An examination of those who dropped out at different times revealed that those who dropped out prior to...Continue Reading

References

Jan 1, 1992·Psychological Medicine. Monograph Supplement·A JablenskyA Bertelsen
Mar 1, 1992·Schizophrenia Research·D AddingtonJ Joyce
Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Jan 1, 1990·Schizophrenia Bulletin·R E DrakeM S Beaudett
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1984·Schizophrenia Bulletin·D W HeinrichsW T Carpenter
Jan 1, 1982·Schizophrenia Bulletin·H E Cannon-SpoorR J Wyatt
Aug 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·W XiongA Kleinman
May 27, 2003·Schizophrenia Research·Jean AddingtonDonald Addington
Feb 26, 2004·Psychological Medicine·J AddingtonD Addington
May 24, 2005·Schizophrenia Research·Jean AddingtonDonald Addington
Dec 13, 2005·Psychiatric Services : a Journal of the American Psychiatric Association·Donald AddingtonCarol Adair
Mar 21, 2006·Schizophrenia Research·Jean Addington, Donald Addington
Apr 11, 2006·Psychiatric Services : a Journal of the American Psychiatric Association·Michael T ComptonDwight Antonio Owens
Jul 26, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Benno Graf SchimmelmannMartin Lambert
Mar 16, 2007·Acta Psychiatrica Scandinavica·J Addington, D Addington
Oct 3, 2008·Schizophrenia Research·Jean Addington, Donald Addington
Apr 28, 2009·Acta Psychiatrica Scandinavica·M A TurnerR T Mulder
Aug 1, 2009·Early Intervention in Psychiatry·Jason A R CarrRahul Manchanda

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Citations

Mar 1, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Grant E SaraWayne C Hall
Sep 15, 2012·Social Psychiatry and Psychiatric Epidemiology·Kelly K AndersonAshok K Malla
May 25, 2016·The Psychiatric Clinics of North America·Anthony O AhmedPeter F Buckley
Feb 11, 2015·The Psychiatric Quarterly·Gerrit Ian van SchalkwykVinod Srihari
May 16, 2015·International Journal of Mental Health Nursing·Rachel TindallBridget Hamilton
Jun 14, 2016·International Journal of Mental Health Nursing·Malene TerpCharlotte D Bjørnes
Oct 12, 2016·Early Intervention in Psychiatry·Robin E GearingJames Mandiberg
Dec 27, 2016·International Journal of Mental Health Nursing·Christopher WagstaffMary Nettle
May 7, 2015·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Emilie LeclercElisa Brietzke
Mar 28, 2018·The International Journal of Social Psychiatry·Juliana OnwumereFiona Gaughran
Sep 14, 2017·Journal of Clinical Psychology in Medical Settings·Jessica Maura, Amy Weisman de Mamani
Jun 22, 2018·Early Intervention in Psychiatry·Worku A TemesgenDaniel Bressington
Feb 6, 2019·Psychiatric Services : a Journal of the American Psychiatric Association·Anika MarajSrividya N Iyer
Oct 28, 2019·Social Psychiatry and Psychiatric Epidemiology·Letizia LeanzaAnita Riecher-Rössler
Mar 30, 2019·Social Psychiatry and Psychiatric Epidemiology·Da Jung KimBrian O'Donoghue
Aug 10, 2020·Early Intervention in Psychiatry·Allison M LoPilatoElaine F Walker
Jul 5, 2018·Early Intervention in Psychiatry·Michael C HannJong Yoon
Sep 21, 2018·Frontiers in Psychology·Juliana OnwumereElizabeth Kuipers
Jul 10, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Juliana OnwumereElizabeth Kuipers
Apr 12, 2017·Frontiers in Psychology·Melanie ClaxtonMiriam Fornells-Ambrojo
Sep 7, 2018·JMIR Mental Health·Juliana OnwumereLucia R Valmaggia
Jul 22, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Francesca SolmiJames B Kirkbride
Jul 20, 2019·Social Psychiatry and Psychiatric Epidemiology·Siobhan ReynoldsBrian O'Donoghue
Nov 26, 2020·Psychiatric Services : a Journal of the American Psychiatric Association·Franco MascayanoLisa B Dixon
Nov 28, 2020·Early Intervention in Psychiatry·Nancy Murillo-GarcíaRosa Ayesa-Arriola
Dec 8, 2020·Early Intervention in Psychiatry·Megan B E WestfallMonica E Calkins
Jan 13, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Nev JonesMichael T Compton
May 22, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Sarah L KopelovichDouglas Turkington
Jul 9, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Benjamin BuckDror Ben-Zeev
Aug 18, 2021·Internet Interventions : the Application of Information Technology in Mental and Behavioural Health·Chelsea ArnoldNeil Thomas

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