Predictors of early acute lung injury at a combat support hospital: a prospective observational study

The Journal of Trauma
Jason W EdensLorne H Blackbourne

Abstract

Acute lung injury (ALI) is a syndrome consisting of noncardiogenic acute hypoxemic respiratory failure with the presence of bilateral pulmonary infiltrates and occurs in up to 33% of critically ill trauma patients. Retrospective and observational studies have suggested that a blood component resuscitation strategy using equal ratios of packed red blood cells (PRBCs) and fresh frozen plasma (FFP) may have a survival benefit in combat casualties. The purpose of this study was to determine whether this strategy is associated with an increased incidence of ALI. We performed a prospective observational study of all injured patients admitted to an intensive care unit (ICU) at a combat support hospital who required >5 units of blood transfusion within the first 24 hours of admission. Baseline demographic data along with Injury Severity Score (ISS), pulmonary injury, presence of long bone fracture, blood products transfused, mechanical ventilation data, and arterial blood gas analysis were collected. The primary endpoint of the study was the development of ALI at 48 hours after injury. Those who did not survive to ICU admission were excluded from analysis. Follow-up (including mortality) longer than 48 hours was unavailable secondary t...Continue Reading

References

Mar 1, 1991·The American Review of Respiratory Disease·A G LjungmanM L Morganroth
Jul 1, 1983·The American Review of Respiratory Disease·M A PopovskyS B Moore
Jul 1, 1982·American Journal of Surgery·P E PepeC J Carrico
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·L D HudsonR J Maunder
Oct 1, 1993·The Journal of Trauma·D B HoytD Fortlage
May 1, 1997·The Journal of Trauma·S M Cohn
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jun 5, 2003·The Journal of Trauma·Debra L MaloneLena M Napolitano
Jul 13, 2004·Transfusion Medicine Reviews·Leslie HolnessPeter A Lachenbruch
Apr 9, 2005·Critical Care Medicine·Pearl ToyUNKNOWN National Heart, Lung and Blood Institute Working Group on TRALI
Apr 15, 2005·Transfusion Medicine Reviews·Mindy GoldmanUNKNOWN TRALI Consensus Panel
Aug 13, 2005·The Journal of Trauma·Martin A CroceTimothy C Fabian
Oct 21, 2005·The New England Journal of Medicine·Gordon D RubenfeldLeonard D Hudson
Apr 18, 2006·Critical Care Medicine·Christopher C Silliman
Jan 12, 2007·The Journal of Trauma·Ernest A GonzalezBruce A McKinley
Feb 14, 2007·The Journal of Trauma·John B HolcombJohn R Hess
Jun 16, 2007·Journal of Applied Physiology·Andriy I BatchinskyLeopoldo C Cancio
Sep 11, 2007·Critical Care Medicine·Philip C SpinellaUNKNOWN 31st Combat Support Hospital Research Working Group
Oct 1, 2008·Critical Care Medicine·Paul E Marik, Howard L Corwin
Nov 13, 2008·The Journal of Trauma·Jason L SperryUNKNOWN Inflammation the Host Response to Injury Investigators
Aug 12, 2009·The Journal of Trauma·Gregory A WatsonUNKNOWN Inflammation and Host Response to Injury Investigators

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Citations

Dec 20, 2011·American Journal of Respiratory Cell and Molecular Biology·Katie L GrinnellElizabeth O Harrington
Apr 24, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Emanuel V GeigerUNKNOWN TraumaRegister DGU®
Apr 25, 2012·Mediators of Inflammation·Birgit AunerBorna Relja
May 6, 2015·Critical Care : the Official Journal of the Critical Care Forum·Marek A MirskiDavid R Holmes
Feb 25, 2015·Journal of Emergencies, Trauma, and Shock·Ryan J KeneallyPeter B Willett
Dec 29, 2017·The Journal of Trauma and Acute Care Surgery·Sawyer SmithMartin Schreiber
Dec 5, 2012·The Journal of Trauma and Acute Care Surgery·Evan M RenzLorne H Blackbourne
Nov 29, 2012·The Journal of Trauma and Acute Care Surgery·Thomas BeinRaymond Fang
Aug 2, 2013·The Journal of Trauma and Acute Care Surgery·Pauline K ParkLena M Napolitano
Apr 24, 2013·The Journal of Trauma and Acute Care Surgery·Ryan Keneally, Dale Szpisjak
Dec 22, 2011·Current Opinion in Anaesthesiology·William M Weightman, Neville M Gibbs
Oct 22, 2016·The Journal of Trauma and Acute Care Surgery·Pauline K ParkLena M Napolitano
Feb 21, 2014·The Journal of Trauma and Acute Care Surgery·Slava M BelenkiyKevin K Chung
Sep 21, 2017·The Journal of Trauma and Acute Care Surgery·Amir ShlaiferUNKNOWN ITG*
Apr 9, 2018·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·George KasotakisUNKNOWN Inflammation and Host Response to Injury Investigators
Sep 7, 2018·Military Medicine·Jeremy CannonZsolt Stockinger
Aug 15, 2013·The Journal of Trauma and Acute Care Surgery·Bryce R H RobinsonUNKNOWN PROMMTT study group
Nov 7, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kamila MoskowitzovaJames D McCully
Sep 18, 2013·The Journal of Trauma and Acute Care Surgery·Elon GlassbergYitshak Kreiss
Sep 24, 2014·The Journal of Trauma and Acute Care Surgery·Martin D ZielinskiUNKNOWN AAST Open Abdomen Study Group
Jun 20, 2013·The Journal of Trauma and Acute Care Surgery·John P SharpeMartin A Croce

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