Predictors of early remission of hyperthyroidism in children

The Journal of Clinical Endocrinology and Metabolism
N S Glaser, D M Styne

Abstract

Children with hyperthyroidism often require prolonged courses of antithyroid medication to achieve remission, and long-term compliance is problematic. To determine which clinical and laboratory features predict early remission, we reviewed the records of 191 patients less than 19 yr old with Graves' disease. We compared patients achieving remission within 2 yr (group 1, n = 27) with those who completed more than 2 yr of medical therapy but did not achieve a remission (group 2, n = 79). Patients who were in neither of the above categories (n = 85) were excluded from the statistical analysis. Variables that were measurable at the time of diagnosis, recorded in more than 50% of the study population and associated with early remission in the univariate analysis (P < or = 0.05), were entered into a stepwise multiple logistic regression analysis. Variables retaining a significant association with early remission (P < 0.05) were considered independent predictors of early remission. Patients achieving early remission were older (mean, 12.5 vs. 10.9 yr, P = 0.039) and had higher body mass indexes (BMI, 19.0 vs. 16.6, P = 0.002), higher BMI SD scores (-0.03 vs. -0.60, P = 0.004), lower heart rates (110 vs. 121, P = 0.023), smaller goiter...Continue Reading

References

Mar 1, 1990·The Journal of Clinical Endocrinology and Metabolism·H AllannicV Derennes
Feb 1, 1990·Clinical Endocrinology·S RatanachaiyavongA M McGregor
Jun 1, 1990·Acta Endocrinologica·B WinsaF A Karlsson
Jun 1, 1987·The Journal of Clinical Endocrinology and Metabolism·B M LippeS A Kaplan
Oct 1, 1987·American Journal of Diseases of Children·C GortonB Senior
Feb 1, 1981·American Journal of Diseases of Children·B A BuckinghamM D Kogut
Aug 1, 1995·Journal of Internal Medicine·R JordeJ Sundsfjord
Jun 16, 1994·The New England Journal of Medicine·J A Franklyn
Aug 1, 1994·European Journal of Endocrinology·C J Edmonds, M Tellez
Jan 1, 1994·The Journal of Clinical Endocrinology and Metabolism·U Feldt-RasmussenP Carayon

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Citations

Jul 23, 2004·Archives of Disease in Childhood·G Birrell, T Cheetham
Jun 27, 2002·The British Journal of Ophthalmology·W ChanJ S K Ng
Mar 13, 2010·International Journal of Pediatric Endocrinology·Scott A RivkeesCatherine Dinauer
Nov 15, 2012·Journal of Clinical Research in Pediatric Endocrinology·Christopher BreuerJulie Ann Sosa
Nov 17, 2012·Journal of Clinical Research in Pediatric Endocrinology·Juliane Léger, Jean Claude Carel
Dec 1, 2011·Molecular Imaging and Radionuclide Therapy·Hülya YalçınAli Balcı
Mar 11, 2008·World Journal of Surgery·Peter StålbergPer Hellman
Oct 21, 2016·Journal of Endocrinological Investigation·S A Rivkees
Feb 27, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·James D WestAnuja Natarajan
Dec 15, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Reuven Zev CohenAndrew B Muir
Aug 5, 2014·International Journal of Pediatric Endocrinology·Scott A Rivkees
Nov 13, 2019·Journal of Endocrinological Investigation·M C VigoneG Weber
Jun 26, 2020·Journal of Endocrinological Investigation·S NamwongpromK Unachak

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