Predictors of first-line antiretroviral therapy failure amongst HIV-infected adult clients at Woldia Hospital, Northeast Ethiopia

PloS One
Yohannes Demissie BaboFasil Walelign Fentaye

Abstract

Due to the limited availability of viral load testing for treatment outcome monitoring in resource limited settings, identifying predictive factors of antiretroviral treatment failure will help in selecting clients who will benefit most from the targeted use of viral load monitoring. Little is known about the predictors of treatment failure in the study area. This study was conducted to determine factors that predict first-line antiretroviral therapy failure among HIV-infected adult clients at Woldia Hospital, Northeast Ethiopia. For this study, antiretroviral therapy treatment failure was defined as the fulfillment of clinical and/or immunological criteria set by WHO. Case-control study was carried out from November to December 2014. Cases were adult clients who were on failing first line regimen and on active follow up while controls were those adult clients on a non-failing first-line regimen for 36 months and above and on active follow up. Data was entered in to Epi Info version 7 and was exported to SPSS version 20 for analysis. Binary logistic regression model was used to identify predictors of ART failure. A total of 59 cases and 245 controls were included in the analysis. Sixty three percent of the participants were fem...Continue Reading

References

Jun 15, 2004·The Journal of Infectious Diseases·Ulrik Bak DragstedUNKNOWN EuroSIDA study group
Apr 17, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Mohammed Ishaaq DatayPatricia Yudkin
Oct 25, 2011·Indian Journal of Sexually Transmitted Diseases and AIDS·B PrabhakarSuresh Sasthri
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Jan 16, 2014·BMC Infectious Diseases·Andargachew MuluMelanie Maier
Jan 18, 2014·Journal of the International AIDS Society·Pauline PenotChristian Laurent

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Citations

Jan 22, 2020·BMC Public Health·Aklilu EndalamawTesfa Dejenie Habtewold

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Software Mentioned

Epi Info
SPSS

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