PMID: 8961376Jan 1, 1996Paper

Predictors of flares and long-term outcome of systemic lupus erythematosus during combined treatment with azathioprine and low-dose prednisolone

Rheumatology International
P OelznerG Stein

Abstract

Many patients with systemic lupus erythematosus (SLE) receive long-term treatment with azathioprine and prednisolone to control disease activity. In a retrospective study we evaluated the efficacy of combined treatment with azathioprine (2 mg/kg body weight/d) and low-dose prednisolone (7-12 mg/d) and the predictors of disease flares during this therapy regimen in 61 patients with SLE. We found three predictors of flares: renal disease, persistence of dsDNA antibodies for at least 1 year after the beginning of treatment and reduction in azathioprine dosage to below 2 mg/kg/d. The occurrence of flares was significantly associated with a higher rate of disease-related death. Furthermore, the persistence of dsDNA antibodies for at least 2 years was associated with progression of renal disease. We concluded that suppression of production of dsDNA antibodies with high avidity is a suitable parameter to determine efficacy of treatment and long-term outcome during combined therapy with azathioprine and low-dose prednisolone in SLE.

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Citations

Oct 20, 2015·Expert Opinion on Pharmacotherapy·M W P Tsang-A-Sjoe, I E M Bultink
Apr 24, 2001·Lupus·M Abu-Shakra, Y Shoenfeld
Oct 27, 2017·Arthritis Research & Therapy·Noémie GensousUNKNOWN FHU ACRONIM
Nov 22, 2013·PloS One·Christian EhrnthallerAnita Ignatius
Apr 11, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido FillerJanusz Feber
Oct 14, 2017·Rheumatology·Caroline GordonUNKNOWN British Society for Rheumatology Standards, Audit and Guidelines Working Group

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