Predictors of health-related quality of life and fatigue in systemic sclerosis: evaluation of the EuroQol-5D and FACIT-F assessment tools.

Clinical Rheumatology
Gemma StricklandNeil McHugh

Abstract

This study evaluates predictors of health-related quality of life (HRQoL) and fatigue in systemic sclerosis (SSc) using two novel self-report indices. A cross-sectional study of patients with SSc was undertaken using a postal questionnaire including the EuroQol-5Domain health questionnaire (EQ-5D™), Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-F) and the Scleroderma Health Assessment Questionnaire (SHAQ). The EQ-5D assesses five domains of health quality and is quantified as a time trade-off (TTO) value and patient global assessment (0-100 visual analogue scale [VAS]). The FACIT-F is a 13-item questionnaire (0-52 scale). Higher scores for both the EQ-5D and FACIT-F indicate better health. Case notes were scrutinised for patient demographics, disease duration, serology and clinical phenotype. Sixty-eight patients (60 females, mean age 62.6 years) completed the questionnaires. Fatigue correlated closely with HRQoL (r (s) = 0.78 and 0.77 for FACIT-F vs. EQ-5D VAS and TTO respectively, p < 0.01) and disability (r (s) = -0.74 for FACIT-F vs. HAQ-DI, p < 0.01). Pain was the most frequently reported health problem (80 %) in the EQ-5D. HRQoL also correlated closely with disability (r (s) = 0.83 for EQ-5D vs. HA...Continue Reading

References

Sep 1, 1995·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·J L PooleP Spitz
Apr 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·P AyatollahiA Tarazi
Jul 9, 2009·Journal of the American College of Cardiology·David B BadeschAdam Torbicki
Aug 1, 2009·Arthritis and Rheumatism·Marie HudsonUNKNOWN Canadian Scleroderma Research Group
Apr 1, 2010·Rheumatology·Dewy van HoogmoedPiet van Riel
Mar 17, 2011·PloS One·Christelle NguyenUNKNOWN Groupe Français de Recherche sur la Sclérodermie

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Citations

Sep 27, 2013·Current Opinion in Rheumatology·Vanessa L MalcarneShadi Gholizadeh
May 3, 2016·Rheumatic Diseases Clinics of North America·Russell E PellarJanet Elizabeth Pope
Sep 12, 2013·Arthritis Care & Research·Julio López-BastidaPedro Serrano-Aguilar
Apr 4, 2016·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Julio López-BastidaUNKNOWN BURQOL-RD Research Network
Dec 19, 2014·Scandinavian Journal of Rheumatology·K ChevreulL Mouthon
Sep 5, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Matylda SierakowskaMwidimi Ndosi
Aug 10, 2021·Therapeutic Advances in Musculoskeletal Disease·Alfredo Madrid-GarcíaLuis Rodríguez-Rodríguez

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