Predictors of heroin relapse: Personality traits, impulsivity, COMT gene Val158met polymorphism in a 5-year prospective study in Shanghai, China

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Hang SuMin Zhao

Abstract

Relapse is a typical feature of heroin addiction and rooted in genetic and psychological determinants. The aim of this study was to evaluate the effect of personality traits, impulsivity, and COMT gene polymorphism (rs4680) on relapse to heroin use during 5-year follow up. 564 heroin dependent patients were enrolled in compulsory drug rehabilitation center. 12 months prior to their release, personality traits were measured by BIS-11 (Barratt Impulsiveness Scale-11) and Temperament and Character Inventory (TCI). The COMT gene rs4680 polymorphism was genotyped using a DNA sequence detection system. The heroin use status was evaluated for 5 years after discharged. Among the 564 heroin-dependent patients, 500 were followed for 5 years after discharge and 53.0% (n = 265) were considered as relapsed to heroin use according to a strict monitor system. Univariate analysis showed that age, having ever been in methadone maintenance treatment (MMT), the total scores and non-planning scores of BIS-11, and the COMT rs4680 gene variants were different between relapse and abstinent groups. Logistic regression analysis showed higher BIS total score, having ever been in MMT and younger first heroin use age are the predictors of relapse to heroi...Continue Reading

References

Mar 1, 1987·Journal of Personality and Social Psychology·C M PattersonJ P Newman
Nov 1, 1995·Journal of Clinical Psychology·J H PattonE S Barratt
Jul 25, 1997·American Journal of Medical Genetics·D J VandenberghH M Lachman
Oct 9, 2003·Acta Psychiatrica Scandinavica·G ParkerK Parker
Mar 6, 2004·Neuromolecular Medicine·Mary Jeanne KreekK Steven LaForge
Mar 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco LeriJane Stewart
Apr 22, 2006·Addictive Behaviors·Giovanni Abbate-DagaSecondo Fassino
Aug 8, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Joseph W VanderVeenDavid R M Trotter
Feb 3, 2009·Biological Psychiatry·Daina EconomidouBarry J Everitt
Aug 12, 2009·BMC Neuroscience·Kara L Kuntz-MelcavageKent E Vrana
Sep 22, 2011·Pharmacogenetics and Genomics·Sarah K JugurnauthGerome Breen
Jan 3, 2012·Behavioral and Brain Functions : BBF·Joanne VoiseyC Phillip Morris
Jan 20, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Gabor VargaMaria Sasvari-Szekely
Feb 27, 2013·Molecular Medicine Reports·Márcio Gerhardt Soeiro-De-SouzaRicardo Alberto Moreno
Mar 7, 2013·Current Opinion in Neurobiology·Tommy Pattij, Taco J De Vries
Dec 3, 2014·Drug and Alcohol Dependence·Eline R ZaaijerWim van den Brink
Dec 17, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Thomas VillemonteixIsabelle Massat

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Citations

Jul 19, 2016·Development and Psychopathology·Michel G NivardChristel M Middeldorp
Oct 16, 2016·Development and Psychopathology·Ian R Gizer
Jan 16, 2018·The American Journal of Drug and Alcohol Abuse·Richard C CristWade H Berrettini
Oct 23, 2019·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Qianying WuMin Zhao
Aug 11, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yuhui ZhuYih-Ing Hser
Dec 5, 2018·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N A FinebergS R Chamberlain
Apr 15, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tianzhen ChenMin Zhao

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