PMID: 7540530Feb 1, 1995Paper

Predictors of human papilloma virus in patients with keratinization

Diagnostic Cytopathology
J HudockA G Jordan

Abstract

Given the prevalence of human papilloma virus (HPV) infection, an attempt was made to determine whether certain factors such as keratinization and/or squamous atypia are associated with its development. Review of our gynecologic cytology files from 1989 yielded 1,615 specimens showing parakeratosis and/or hyperkeratosis, without cytologic evidence of HPV. Concomitant diagnoses included no atypia [keratinization only (KO)], inflammatory squamous atypia (ISA), and squamous atypia (SA). Morphologic follow-up including repeat cytology or biopsy was available for 916 cases, 92 (10.0%) of which possessed changes of HPV. For any case with both cytologic and biopsy evidence of HPV, only the biopsy result was tabulated. HPV on follow-up examination was detected in 52 (6.7%) of the 764 cases with KO; in 20 (20.8%) of the 96 cases with keratinization and ISA (KISA); and in 20 (35.7%) of the 56 cases with keratinization and SA (KSA). The definitive diagnosis of HPV was based on previously described features (Gupta, In: Comprehensive Cytopathology, Philadelphia: WB Saunders, 1991:133-140) including nuclear enlargement with nuclear membrane irregularities in combination with sharply demarcated paranuclear cytoplasmic clearing. Affected cells...Continue Reading

References

Mar 1, 1990·American Journal of Obstetrics and Gynecology·A T LorinczG F Temple
Nov 1, 1990·Obstetrics and Gynecology·S CecchiniG Cipparrone
Feb 25, 1989·Lancet·T P Jenkins
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May 15, 1987·Cancer·H zur Hausen

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Citations

Feb 24, 2001·American Journal of Clinical Pathology·W C FaquinE S Cibas
Jan 4, 1998·Diagnostic Cytopathology·M NavarroG J Nuovo

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