Predictors of improvement in cardiometabolic risk factors with weight loss in women

Journal of the American Heart Association
Caitlin A DowCheryl L Rock

Abstract

Weight loss is associated with improvements in cardiometabolic risk factors, including serum glucose, insulin, C-reactive protein, and blood lipids. Few studies have evaluated the long-term (>18 months) effect of weight loss on these risk factors or sought to identify factors associated with sustained improvements in these measures. In 417 overweight/obese women (mean [SD] age, 44 [10] years) participating in a weight loss trial, we sought to identify predictors of weight loss-associated cardiometabolic risk factors after 12 and 24 months of intervention. Total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol (LDL-C), high-density lipoprotein (HDL)-cholesterol, non-HDL-cholesterol, triglycerides (TG), insulin, glucose, C-reactive protein (CRP), and cardiopulmonary fitness were measured at baseline and at 12 and 24 months. After 24 months, significant reductions in body weight, waist circumference, CRP, TC, HDL-cholesterol, and non-HDL-cholesterol were observed (P<0.01). After 24 months, mean TC and non-HDL-cholesterol were reduced regardless of the amount of weight lost, whereas reductions in LDL-cholesterol, CRP, insulin, and TG were observed only in those who lost ≥10% body weight. Step-test performance improved on...Continue Reading

Associated Clinical Trials

References

May 29, 1998·Circulation·P W WilsonW B Kannel
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 21, 2005·JAMA : the Journal of the American Medical Association·Edward W GreggDavid F Williamson
Jan 8, 2008·The American Journal of Clinical Nutrition·Peter M CliftonManny Noakes
Jul 24, 2008·Journal of Clinical Biochemistry and Nutrition·Naoto FukuyamaEtsuro Tanaka
Aug 28, 2009·Metabolism: Clinical and Experimental·Sarah M CamhiDeborah Rohm Young
Dec 22, 2009·The Journal of Clinical Hypertension·Erik P Kirk, Samuel Klein
Dec 22, 2009·Maturitas·Conrad P EarnestTimothy S Church
Dec 24, 2009·Diabetes·Jeanine B AlbuUNKNOWN Look AHEAD Adipose Research Group
Jan 21, 2010·American Journal of Physiology. Endocrinology and Metabolism·Tore ChristiansenBjørn Richelsen
Jun 10, 2010·Current Opinion in Lipidology·Ronald M Krauss
Oct 6, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M N HarvieA Howell
Jun 3, 2011·The Journal of Clinical Investigation·Carey N Lumeng, Alan R Saltiel
Jul 20, 2011·Lipids in Health and Disease·Krista A VaradyCynthia M Kroeger
Sep 29, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Deepika LadduScott Going
Oct 4, 2011·The American Journal of Medicine·William D JohnsonDonna H Ryan
Nov 24, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M AshwellS Gibson
Dec 29, 2011·Current Atherosclerosis Reports·Jamal S RanaPrediman K Shah

❮ Previous
Next ❯

Citations

Jul 4, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Eve NormandinMartin Brochu
Feb 26, 2015·Diabetes·Tove FallUNKNOWN ENGAGE Consortium
Aug 26, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ouarda Taleb-BelkadiKhedidja Mekki
Dec 8, 2017·Zeitschrift für Psychosomatische Medizin und Psychotherapie·Stephan HerpertzSebastian Jongen
May 20, 2014·Current Opinion in Cardiology·Bruce A Griffin
Jul 30, 2019·BioMed Research International·Hayfaa A WahabiHanadi Bakhsh
Apr 24, 2018·Rheumatology·Sally ThomasMargaret P Rayman
Mar 28, 2021·Current Atherosclerosis Reports·Kelsey GabelKrista A Varady
Apr 7, 2015·Annals of Internal Medicine·Kimberly A GudzuneJeanne M Clark

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.