Predictors of in-hospital mortality and the risk of symptomatic intracerebral hemorrhage after thrombolytic therapy with recombinant tissue plasminogen activator in acute ischemic stroke

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Mohamed Al-KhaledJürgen Eggers

Abstract

Recombinant tissue-plasminogen activator (rt-PA) therapy improves functional outcome in patients with acute ischemic stroke (AIS) but is associated with serious complications, including symptomatic intracerebral hemorrhage (sICH). This study aimed to determine the independent predictors of in-hospital mortality (IHM) and the risk of sICH after rt-PA therapy. A total of 1007 patients (mean age, 72 ± 12 years; 52% women; mean National Institutes of Health Stroke Scale [NIHSS] score, 11.6 ± 5.6) with AIS treated with rt-PA were enrolled in this study during a 42-month period beginning in November 2007. Univariate and multivariate regression analyses were performed to estimate the predictors of IHM. Eighty-three of the 1007 patients (8.2%) died during hospitalization (mean duration of hospitalization, 10 ± 1.8 days). Logistic regression estimated the following independent predictors for IHM: age ≥80 years (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-3.0; P = .031), aphasia (OR, 2.0; 95% CI, 1.1-3.4; P = .017), altered consciousness (OR, 3.6; 95% CI, 2.0-6.2; P < .001), hypertension (OR, 4; 95% CI, 1.4-11.6; P = 0.012), sICH (OR, 5.9; 95% CI, 2.9-11.9; P < 0.001), and pneumonia during hospitalization (OR, 3.0; 95% CI, 1....Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Oct 21, 2004·JAMA : the Journal of the American Medical Association·Peter U HeuschmannUNKNOWN German Stroke Registers Study Group
Oct 19, 2011·Cerebrovascular Diseases·Hans T H TuUNKNOWN VISTA collaborators
Nov 5, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B FuentesUNKNOWN Madrid Stroke Network

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Citations

Jun 9, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Toralf Bruening, Mohamed Al-Khaled
Apr 5, 2018·International Journal of Speech-language Pathology·Victoria JonesAnna Copley
May 27, 2017·Stroke; a Journal of Cerebral Circulation·Lars KellertUNKNOWN SITS Investigators
Jan 31, 2019·Clinical and Experimental Pharmacology & Physiology·Chaoming HeYing Tang
Aug 20, 2020·Stroke; a Journal of Cerebral Circulation·Wai M YuUNKNOWN SITS Scientific Committee*
Dec 29, 2016·Internal and Emergency Medicine·Renata Dal-Prá DucciViviane de Hiroki Flumignan Zétola
Dec 19, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Justyna DerbiszAgnieszka Slowik
Apr 2, 2021·The American Journal of Emergency Medicine·Karly A DancsecsAaron M Cook

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