Predictors of intractable epilepsy in childhood: a case-control study

Epilepsia
A T BergS Shinnar

Abstract

Little is known about what factors predict intractable epilepsy at the time of initial diagnosis. We performed a case-control study to identify early predictors of medically intractable epilepsy in children. Cases were children who had an average of one seizure or more a month over a 2-year period and who, during that time, had failed trials of at least three different antiepileptic drugs (AEDs). Controls were children who had epilepsy, who had been seizure-free for > or = 2 years, and who had never, before becoming seizure-free, met the definition for intractable epilepsy. Strong univariate associations were noted between intractability and several factors: infantile spasms (IS) remote symptomatic epilepsy, a history of status epilepticus (SE) before the diagnosis of epilepsy, neonatal seizures, and microcephaly. Cases were significantly younger than controls at onset (1.8 vs. 5.8 years); this was not due solely to cases with onset during the first year of life but was an association apparent throughout the age range studied. With multiple logistic regression, independent predictors of intractability were IS, odds ratio (OR) = 10.42, p = 0.03; age at onset with a decreasing risk with increasing age, OR = 0.77 per year, p less ...Continue Reading

References

Jan 1, 1979·Journal of Chronic Diseases·D L Sackett
Dec 1, 1979·Epilepsia·J F AnnegersL R Elveback
Nov 4, 1976·The New England Journal of Medicine·K B Nelson, J H Ellenberg
Jun 1, 1992·Annals of Neurology·S ShinnarS L Moshe
Nov 1, 1990·Annals of Neurology·P R Huttenlocher, R J Hapke
Dec 1, 1990·Seminars in Neurology·R H Mattson
Oct 11, 1984·The New England Journal of Medicine·R D ElwesE H Reynolds
Aug 1, 1984·Developmental Medicine and Child Neurology·G B CavazzutiM Lalla
Jul 28, 1995·Pharmacy World & Science : PWS·L de Jong-van den Berg, B Mintzes
Oct 1, 1994·Developmental Medicine and Child Neurology·P CamfieldJ Dooley
Jan 1, 1993·Epilepsia·V Gross-Tsur, S Shinnar

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Citations

May 1, 1997·Neuropsychologia·S A Baxendale
Oct 24, 2002·Pediatric Neurology·Sanjay ChawlaVenkatesan Mallika
Sep 19, 2003·Pediatric Neurology·Karen L KwongKwan T So
Aug 28, 1999·Pediatric Neurology·M SillanpääS Shinnar
Jul 28, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·T S Ko, G L Holmes
Jun 12, 1998·The New England Journal of Medicine·M SillanpääS Shinnar
May 20, 1999·The New England Journal of Medicine·O Devinsky
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
Jan 21, 2009·Brain : a Journal of Neurology·Matti Sillanpää, Dieter Schmidt
Apr 14, 2012·Brain : a Journal of Neurology·Matti Sillanpää, Dieter Schmidt
Dec 4, 2003·Clinical Neuropharmacology·Emilia M GattoFederico Micheli
Mar 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A T Berg, S Shinnar
Sep 15, 2012·Journal of Paediatrics and Child Health·Yu-Tze Ng, Rama Maganti
Nov 17, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M A KimM K Oh
Jan 1, 2010·Neuromodulation : Journal of the International Neuromodulation Society·Won Chul NamgungJung-Kyo Lee
Jan 29, 2011·Epilepsia·Brian CallaghanJacqueline French
Sep 2, 2008·Neurosurgical Focus·Cristina Go, O Carter Snead
Jan 1, 2010·Neurology International·Stylianos GatzonisVasilios K Kimiskidis
Jul 10, 2003·Lancet Neurology·Susan S Spencer
Aug 12, 2014·Indian Journal of Pediatrics·Satinder Aneja, Puneet Jain
Dec 2, 2014·Neurophysiologie clinique = Clinical neurophysiology·N André-ObadiaM D Lamblin
Jun 18, 1999·Brain & Development·A BeilmannT Talvik
Mar 17, 2007·Scandinavian Journal of Infectious Diseases·Aviv Schupper, Avinoam Shuper
Jan 1, 2003·Expert Review of Neurotherapeutics·Deborah E Briggs, Jacqueline A French
Nov 9, 2005·Expert Review of Neurotherapeutics·Amit Ray, Elaine Wyllie
Jul 21, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Sosuke YoshikawaHiroshi Tamai
Aug 17, 2014·Epilepsy & Behavior : E&B·Lisu HuangLing Li
Jun 27, 2014·Epilepsy & Behavior : E&B·Vaishnavi PurusothamanDavid D Limbrick
Jan 6, 2016·Epilepsy & Behavior : E&B·Giorgia GiussaniUNKNOWN EPIRES Group
Jan 8, 2013·Pediatric Neurology·Berna Seker YilmazMustafa Komur
Sep 3, 2002·Annals of Neurology·Matti Sillanpää, Shlomo Shinnar
Nov 9, 2011·Seminars in Pediatric Neurology·M Scott Perry, Michael Duchowny
Oct 12, 2010·Pediatric Neurology·Maria HnojcikováElaine C Wirrell
Jan 30, 2010·Seminars in Perinatology·Sujatha Kannan, Harry T Chugani

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