Predictors of intramedullary lesion expansion rate on MR images of patients with subaxial spinal cord injury

Journal of Neurosurgery. Spine
Elizabeth LeNoori Akhtar-Danesh

Abstract

OBJECT Studies of preclinical spinal cord injury (SCI) in rodents indicate that expansion of intramedullary lesions (IMLs) seen on MR images may be amenable to neuroprotection. In patients with subaxial SCI and motor-complete American Spinal Injury Association (ASIA) Impairment Scale (AIS) Grade A or B, IML expansion has been shown to be approximately 900 μm/hour. In this study, the authors investigated IML expansion in a cohort of patients with subaxial SCI and AIS Grade A, B, C, or D. METHODS Seventy-eight patients who had at least 2 MRI scans within 6 days of SCI were enrolled. Data were analyzed by regression analysis. RESULTS In this cohort, the mean age was 45.3 years (SD 18.3 years), 73 patients were injured in a motor vehicle crash, from a fall, or in sport activities, and 77% of them were men. The mean Injury Severity Score (ISS) was 26.7 (SD 16.7), and the AIS grade was A in 23 patients, B in 7, C in 7, and D in 41. The mechanism of injury was distraction in 26 patients, compression in 22, disc/osteophyte complex in 29, and Chance fracture in 1. The mean time between injury onset and the first MRI scan (Interval 1) was 10 hours (SD 8.7 hours), and the mean time to the second MRI scan (Interval 2) was 60 hours (SD 29.6...Continue Reading

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Citations

Apr 11, 2017·Annals of Neurology·Eveline HuberPatrick Freund
Apr 8, 2017·Journal of Neurotrauma·Kathirkamanathan ShanmuganathanStuart E Mirvis
Dec 20, 2020·Journal of Neurotrauma·Steven KirshblumJames Guest
Dec 24, 2020·Journal of Neurotrauma·Bizhan AarabiMaureen Scarboro
Feb 3, 2019·Radiologic Clinics of North America·Jason F TalbottSanjay S Dhall
Jun 1, 2021·Neurosurgery Clinics of North America·Saman ShabaniMarjorie C Wang

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