Predictors of loss of asthma control induced by corticosteroid withdrawal.

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Jose BeldaFrederick E Hargreave

Abstract

Asthma guidelines recommend reducing the dose of inhaled corticosteroids after establishing control. To identify predictors of loss of control and the kinetics of symptoms, and inflammatory and physiological measurements when inhaled corticosteroids are reduced in patients with stable asthma. In a single-blind study, the daily dose of inhaled corticosteroid was reduced by one-half at intervals of 20+/-2 days in 17 adults with controlled asthma until loss of asthma control occurred or until the corticosteroid was replaced with placebo for 20 days. The patients recorded symptoms and peak expiratory flow each day, and forced expiratory volume in 1 s (FEV1), the provocative concentration of methacholine causing a 20% fall in FEV1 (PC20), exhaled nitric oxide, and eosinophils in sputum and blood were measured every 10 days. A loss of asthma control was defined as a worsening of the symptoms score of at least 20%, and either a decrease in FEV1 of at least 15% or a decrease in PC20 of at least fourfold. Two patients had a respiratory infection and were withdrawn from the study. In eight patients, asthma became uncontrolled after a mean of 33 days (range 13 to 48 days). This was accurately reflected by a worsening of all parameters. Th...Continue Reading

Citations

Oct 28, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·M Bradley DrummondUNKNOWN American Lung Association Asthma Clinical Research Center Research Group
May 3, 2013·Current Opinion in Allergy and Clinical Immunology·Steven Greenberg
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Frederick E Hargreave
May 15, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A I FanatR Sehmi
Mar 28, 2017·Frontiers in Immunology·Gilda VarricchiGiorgio Walter Canonica
Mar 9, 2010·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Ebrahim Razi, Gholam Abbass Moosavi
Dec 1, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-L MaloK Maghni
Feb 2, 2017·The Cochrane Database of Systematic Reviews·Iain CrossinghamPaul A Marsden
Oct 29, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Marlous M S SneeboerElisabeth H D Bel
Feb 1, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S DemarcheT Van Hees
Jun 20, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P BrinkmanN Fens
Apr 6, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jung-Hyun KimTae-Bum Kim
Aug 21, 2009·Respiratory Medicine·Louis-Philippe BouletMichel Laviolette

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