Predictors of maternal and fetal complications in SLE patients: a prospective study

Immunologic Research
Elisabetta BorellaA Doria

Abstract

The aim of the study was to evaluate predictors of disease flares during pregnancy and obstetric and fetal complications in a cohort of systemic lupus erythematosus (SLE) patients. One hundred and thirty-two pregnancies in 96 SLE patients were prospectively followed by monthly clinical and laboratory evaluations. Predictors of lupus flares, fetal and obstetric complications during pregnancy were identified performing stepwise logistic regression analysis. Maternal lupus flares occurred in 57 % of pregnancies and were being best predicted by the number of flares before conception. Manifestations during flares were best predicted by the same features occurred before conception: dermatological flares by skin rash, renal flares by nephritis, and hematological flares by hematological abnormalities. There were 110 live births and 22 fetal losses. Among live newborns, 22 % were premature. Fetal loss was best predicted by hypertension at conception; miscarriages by the amount of steroids taken during the last year before conception; stillbirth by the number of flares during the last year before conception; preterm birth by the coexistence of anti-phospholipid antibody syndrome and anti-double-stranded DNA antibody levels before concept...Continue Reading

References

Dec 1, 1985·Clinics in Rheumatic Diseases·M D Lockshin
Dec 14, 2004·Arthritis and Rheumatism·Andrea DoriaMaurizio Cutolo
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Eliza F ChakravartyMaurice L Druzin
Jul 21, 2006·Annals of the New York Academy of Sciences·Andrea DoriaSilvano Todesco
Aug 5, 2006·The American Journal of Medicine·Andrea DoriaSilvano Todesco
Dec 13, 2006·Lupus·A TincaniUNKNOWN Pregancy Study Group of Italian Socitety of Rheumatology
Jun 21, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Enrico ImbasciatiDaniele Marcelli
Jun 27, 2009·Clinical Reviews in Allergy & Immunology·Paula AmbrósioFátima Serrano
Jul 16, 2009·Clinical Reviews in Allergy & Immunology·Graziela CarvalheirasCarlos Vasconcelos
Aug 4, 2010·Archives of Gynecology and Obstetrics·Neelam AggarwalAman Sharma
Aug 7, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Andrew SmythVesna D Garovic
Mar 12, 2011·Clinical Reviews in Allergy & Immunology·Haruko IdeguchiYoshiaki Ishigatsubo
Jun 3, 2011·The Journal of Rheumatology·Kate BramhamCatherine Nelson-Piercy
Jul 2, 2011·Annals of the Rheumatic Diseases·Elena SanchezAmr H Sawalha
Aug 31, 2011·Autoimmunity·Valentina CantiPatrizia Rovere-Querini
Mar 16, 2012·Arthritis Research & Therapy·Andrea DoriaMichelle Petri
Aug 22, 2012·Nature Reviews. Rheumatology·Aisha Lateef, Michelle Petri
Sep 25, 2012·Autoimmunity Reviews·Mariele GattoAndrea Doria
Mar 8, 2013·Journal of Internal Medicine·V Oke, M Wahren-Herlenius
Jun 12, 2013·Arthritis and Rheumatism·Michelle A PetriUNKNOWN BLISS-52 and BLISS-76 Study Groups
Jun 29, 2013·Archives of Gynecology and Obstetrics·Riza MadazliHandan Yilmaz
Aug 7, 2013·Current Opinion in Rheumatology·Monika Ostensen, Megan Clowse
Oct 8, 2013·Lupus·O Ateka-Barrutia, M A Khamashta
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Aisha Lateef, Michelle Petri
Feb 5, 2014·Obstetrics and Gynecology Clinics of North America·William H Kutteh, Candace D Hinote

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Citations

Jun 7, 2016·Clinics in Dermatology·Joy WanVictoria P Werth
Nov 26, 2014·Immunologic Research·Eric RosenthalYehuda Shoenfeld
Aug 8, 2015·Autoimmune Diseases·Guilherme Ramires de JesusRoger Abramino Levy
May 5, 2016·European Journal of Internal Medicine·Gabriella Moroni, Claudio Ponticelli
Oct 26, 2016·Journal of Autoimmunity·Gabriella MoroniMarta Mosca
Oct 26, 2016·Journal of Autoimmunity·Maria Grazia LazzaroniAngela Tincani
Aug 2, 2016·Case Reports in Obstetrics and Gynecology·Tayfun Akalinİbrahim Koçak
Jul 6, 2017·Current Opinion in Rheumatology·Laura AndreoliAngela Tincani
May 17, 2018·Expert Review of Clinical Immunology·Gabriella Moroni, Claudio Ponticelli
Aug 30, 2019·Current Opinion in Rheumatology·Wendy Marder
Sep 10, 2020·Birth Defects Research·Aleksandra Polić, Sarah G Običan
Oct 1, 2016·Annual Review of Medicine·Lisa R Sammaritano
Aug 27, 2015·Fertility Research and Practice·Bonnie L Bermas, Lisa R Sammaritano
Jun 5, 2018·Case Reports in Obstetrics and Gynecology·Matthew J Blitz, Adiel Fleischer
Apr 1, 2020·International Journal of Rheumatic Diseases·Miguel Ángel SaavedraLuis Javier Jara
Jan 20, 2021·Annals of the Academy of Medicine, Singapore·Yih Jia PohLay Kok Tan
May 21, 2021·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists’ Committee on Obstetric Practice, Society for Maternal-Fetal Medicine

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