Predictors of Mucosal and Muscle Pain in Vulvodynia: A Cross-Sectional Analysis From the National Vulvodynia Registry.

The Journal of Pain : Official Journal of the American Pain Society
Lydia LoAndrea Rapkin

Abstract

Diagnostic criteria for provoked vestibulodynia (PVD) rely on mucosal pain in the vulvar vestibule, with less emphasis on pain from pelvic floor muscles. It is unknown how psychosocial variables associated with PVD are differentially associated with mucosal versus muscle pain. Analysis of data from the National Vulvodynia Registry (n = 202) revealed several factors associated with increased mucosal pain: pain duration (P = .043), the McGill sensory subscore (P = .0086) and the Gracely pain scale (P< .001). Increased mucosal pain was also associated with decreased arousal (P = .036). On the other hand, factors significantly associated with greater muscle pain included number of comorbid pain conditions (P = .001), decreased intercourse frequency post PVD onset (P = .02) and higher scores on the McGill sensory (P = .0001) and affective (P = .0002) subscores, the Gracely pain scale (P = .0012), and state anxiety (P < .001). Sexual function was also significantly impacted by high pelvic floor muscular pain, with lower scores for arousal (P = .046), orgasm (P = .0014) and satisfaction (P = .013), and higher pain (P = .01). Significant differences in the relationship between muscle and mucosal pain for pain duration (P = .005), McGil...Continue Reading

References

Mar 1, 1992·Pain·R H Gracely
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jul 30, 2005·Journal of Psychosomatic Obstetrics and Gynaecology·E D ReissingS Khalifé
Mar 2, 2006·Obstetrics and Gynecology·Lauren D ArnoldGeorge G Rhoads
Jun 23, 2009·The Clinical Journal of Pain·Geneviève DesrochersMélanie Jodoin
Nov 3, 2009·Behaviour Research and Therapy·Geneviève DesrochersMélanie Jodoin
Jan 12, 2010·The Journal of Sexual Medicine·Evelyne Gentilcore-SaulnierSusan Chamberlain
May 1, 2010·American Journal of Obstetrics and Gynecology·Martha F GoetschCatherine M Leclair
Oct 4, 2011·American Journal of Obstetrics and Gynecology·Barbara Diane ReedHope Katharine Haefner
Aug 24, 2012·Obstetrics and Gynecology·Barbara D ReedHope K Haefner
Sep 11, 2012·The Journal of Pain : Official Journal of the American Pain Society·Denniz ZolnounWilliam Maixner
Dec 19, 2013·The Journal of Sexual Medicine·Mélanie MorinYitzchak M Binik
Jul 1, 2014·The Clinical Journal of Pain·Seth Nicholas P DavisMarc Steben
Sep 5, 2014·The Journal of Sexual Medicine·Andrew T GoldsteinIrwin Goldstein
Jul 15, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Brittney P CiszekAndrea G Nackley
Sep 1, 2015·Journal of Pain Research·Kathryn WitzemanDenniz Zolnoun
Dec 26, 2015·Journal of Lower Genital Tract Disease·Barbara D ReedAnanda Sen
Jan 12, 2016·Journal of Women's Health·Barbara D ReedAnanda Sen
Apr 6, 2016·The Journal of Sexual Medicine·Andrew T GoldsteinSusan Kellogg-Spadt
Jun 18, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·M L FalsettaR P Phipps
Jul 26, 2017·Journal of Pain Research·Meryl AlappattuAndrea Rapkin
Oct 6, 2017·International Journal of Women's Health·Helen HenzellJennifer P Langford
Oct 27, 2017·Journal of Pain Research·Serena Corsini-MuntNatalie O Rosen
Mar 13, 2018·The Clinical Journal of Pain·Justine Benoit-PiauMélanie Morin
Jul 24, 2018·The Journal of Sexual Medicine·Félix FontaineMélanie Morin
Aug 28, 2019·The Journal of Sexual Medicine·Myriam PâquetSophie Bergeron

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