Predictors of Outcome During Eplerenone Therapy in Chronic Central Serous Chorioretinopathy:A Prospective, Open-Label Pilot Clinical Study

Ophthalmic Surgery, Lasers & Imaging Retina
Bindu RajeshJay Chhablani

Abstract

To assess the treatment response and predictive factors following eplerenone treatment in chronic central serous chorioretinopathy (CSCR). A prospective, nonrandomized study involving fixed-dose eplerenone was conducted in 22 eyes of 11 consecutive patients with bilateral chronic CSCR. The changes in subretinal fluid (SRF), central macular thickness (CMT), and best-corrected visual acuity (BCVA) were analyzed. A significant reduction in SRF was observed in 13 of 16 eyes with baseline SRF (81.25%) at 3 months (P < .04), with complete resolution in six eyes (37.5%) at 3 months and in 10 eyes (62.5%) at 6 months (P < .006). Baseline BCVA was a significant predictor of final BCVA (P < .001), whereas 3-month SRF height was a weak but significant predictor of the 6-month height (r2 = 0.53; P = .002). When treated with eplerenone, chronic CSCR shows a significant reduction in SRF, with baseline BCVA and 3-month SRF height being important predictive factors. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:479-486.].

References

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Citations

May 13, 2019·The British Journal of Ophthalmology·Daniel S PetkovsekRishi P Singh
Sep 11, 2019·Journal of Clinical Medicine·Maciej GawęckiAndrzej Grzybowski
Sep 14, 2019·International Journal of Retina and Vitreous·Hamid-Reza MoeinAndré J Witkin
Dec 9, 2020·The British Journal of Ophthalmology·Sumit Randhir SinghJay Chhablani
Jul 19, 2019·Progress in Retinal and Eye Research·Thomas J van RijssenCamiel J F Boon

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