Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility

The Journal of Clinical Endocrinology and Metabolism
Babak ImaniBart C J M Fauser

Abstract

The diagnostic criteria used to identify patients suffering from polycystic ovary syndrome remain controversial. The present prospective longitudinal follow-up study was designed to identify whether certain criteria assessed during standardized initial screening could predict the response to ovulation induction with clomiphene citrate (CC) in 201 patients presenting with oligomenorrhea or amenorrhea and infertility. Serum FSH levels were within the normal range (1-10 IU/L), and all patients underwent spontaneous or progestin-induced withdrawal bleeding. Initial CC doses were 50 mg daily for 5 days starting on cycle day 3. In the case of an absent response, doses were increased to 100 and 150 mg daily in subsequent cycles. First ovulation with CC was used as the end point. After a complete follow-up (in the case of a nonresponse, at least 3 treatment cycles with daily CC doses up to 150 mg), 156 patients (78%) ovulated. The free androgen index (FAI = testosterone/sex hormone-binding globulin ratio), body mass index (BMI), cycle history (oligomenorrhea vs. amenorrhea), serum androgen (testosterone and/or androstenedione) levels, and mean ovarian volume assessed by transvaginal sonography were all significantly different (P < 0.01...Continue Reading

Associated Clinical Trials

Citations

Mar 29, 2008·Human Reproduction·Anders Nyboe AndersenUNKNOWN Bravelle Ovulation Induction (BOI) Study Group
Jan 7, 2011·Journal of Human Reproductive Sciences·Shilpi PandeySiladitya Bhattacharya
Feb 18, 2006·Journal of Endocrinological Investigation·F P HohmannB C J M Fauser
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Roy Homburg
Nov 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Richard S LegroUNKNOWN Reproductive Medicine Network
Oct 1, 2005·Archives of Gynecology and Obstetrics·Nikiforos BallianGregory A Kaltsas
May 7, 2016·Reproductive Biomedicine Online·Kathrine Birch PetersenNina la Cour Freiesleben

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