Predictors of persistently positive Mycobacterium-tuberculosis-specific interferon-gamma responses in the serial testing of health care workers.

BMC Infectious Diseases
Felix C RingshausenGernot Rohde

Abstract

Data on the performance of Mycobacterium-tuberculosis-specific interferon-(IFN)-gamma release assays (IGRAs) in the serial testing of health care workers (HCWs) is limited. The objective of the present study was to determine the frequency of IGRA conversions and reversions and to identify predictors of persistent IGRA positivity among serially tested German HCWs in the absence of recent extensive tuberculosis (TB) exposure. In this observational cohort-study HCWs were prospectively recruited within occupational safety and health measures and underwent a tuberculin skin test (TST) and the IGRA QuantiFERON-TB Gold In-Tube (QFT-GIT) at baseline. The QFT-GIT was repeated 18 weeks later in the median. QFT-GIT conversions (and reversions) were defined as baseline IFN-gamma < 0.35 IU/ml and follow-up IFN-gamma > or = 0.35 IU/ml (and vice versa). Predictors of persistently positive QFT-GIT results were calculated by logistic regression analysis. In total, 18 (9.9%) and 15 (8.2%) of 182 analyzed HCWs were QFT-GIT-positive at baseline and at follow-up, respectively. We observed a strong overall agreement between baseline and follow-up QFT-GIT results (kappa = 0.70). Reversions (6/18, 33.3%) occurred more frequently than conversions (3/16...Continue Reading

References

Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·D Menzies
Apr 16, 2005·Respiratory Research·Roland DielStefan Niemann
May 4, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nobuyuki HaradaToru Mori
May 13, 2006·American Journal of Respiratory and Critical Care Medicine·Madhukar PaiDick Menzies
Jun 27, 2006·American Journal of Respiratory and Critical Care Medicine·Katie EwerAjit Lalvani
Apr 10, 2007·Trends in Molecular Medicine·Peter AndersenKarin Weldingh
Jun 15, 2007·PLoS Medicine·Philip C HillKeith P McAdam
Jul 3, 2007·International Archives of Occupational and Environmental Health·A NienhausR Diel
Oct 11, 2007·Das Gesundheitswesen·R DielUNKNOWN German Central Committee against Tuberculosis
Jan 18, 2008·Clinical and Vaccine Immunology : CVI·Sharon PerryJulie Parsonnet
Oct 22, 2008·Annals of Internal Medicine·Mustafa BakirAjit Lalvani
Feb 5, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Paul VintonBeverley-Ann Biggs
Feb 25, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nira R PollockAntonio Campos-Neto
Mar 3, 2009·BMC Infectious Diseases·Samantha RibeiroSusan E Dorman
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Richard N van Zyl-SmitKeertan Dheda
Jun 10, 2009·Journal of Occupational Medicine and Toxicology·Felix C RingshausenGernot Rohde
Jun 19, 2009·Clinical and Vaccine Immunology : CVI·A K DetjenA C Hesseling
Jul 30, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·C B E CheeY T Wang
Oct 21, 2009·The European Respiratory Journal·S V KikS Verver
Nov 26, 2009·Annals of Clinical Microbiology and Antimicrobials·Felix C RingshausenGernot Rohde
Jan 31, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·N SinglaD Behera

❮ Previous
Next ❯

Citations

Aug 20, 2010·International Archives of Occupational and Environmental Health·José Torres CostaAlbert Nienhaus
Mar 5, 2011·QJM : Monthly Journal of the Association of Physicians·O M P Jolobe
May 20, 2011·Clinical and Vaccine Immunology : CVI·Felix C RingshausenGernot Rohde
Oct 30, 2012·American Journal of Respiratory and Critical Care Medicine·John Z MetcalfeEdward A Graviss
Sep 21, 2011·BMC Infectious Diseases·Anja SchablonAlbert Nienhaus
Apr 28, 2012·Journal of Occupational Medicine and Toxicology·Felix C RingshausenAlbert Nienhaus
Sep 13, 2012·PloS One·William C WhitworthGerald H Mazurek
Jan 28, 2014·PloS One·William C WhitworthGerald H Mazurek
Jun 24, 2014·The Journal of Infection·Nguyen Thi Le HangNaoto Keicho
Feb 19, 2015·Infectious Diseases·Juan Gonzślez-MorenoAntoni Payeras Cifre
Feb 23, 2013·Expert Review of Anti-infective Therapy·Albert NienhausDominique Tripodi
May 27, 2014·Clinics in Laboratory Medicine·Robert Belknap, Charles L Daley
Feb 27, 2016·Enfermedades infecciosas y microbiología clínica·Miguel SantinUNKNOWN Panel of experts from the Mycobacteria Study Group (GEIM) of the Spanish Society of Infectious Diseases and Clinical Microbi
Jan 24, 2015·Enfermedades infecciosas y microbiología clínica·Xavier Martinez-LacasaEva Cuchi
Jul 23, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mulugeta BelayFekadu Abebe
Jun 3, 2014·The Tohoku Journal of Experimental Medicine·Kwang Won SeoYangjin Jegal
Feb 17, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jean-Christophe LucetUNKNOWN QUANTIPS Study Group
Jan 30, 2015·The Journal of Infectious Diseases·Maximilian C Aichelburg
Apr 13, 2012·Infectious Diseases in Obstetrics and Gynecology·Sasi R JonnalagaddaGrace C John-Stewart
Aug 26, 2014·Journal of the International Association of Providers of AIDS Care·Andrea T CruzJeffrey R Starke
Jan 8, 2014·Clinical Microbiology Reviews·Madhukar PaiNiaz Banaei
May 28, 2016·The European Respiratory Journal·Lei GaoUNKNOWN LATENTTB-NSTM study team
Nov 18, 2017·The European Respiratory Journal·Jonathan W UzorkaSandra M Arend
May 22, 2020·Indian Journal of Occupational and Environmental Medicine·Thana KhawcharoenpornBenjawan Phetsuksiri
Sep 12, 2019·Frontiers in Pediatrics·Maurizio de MartinoElena Chiappini

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

GIT
SPSS
QFT

Related Concepts

Related Feeds