Predictors of poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A multiinstitutional review

Journal of Pediatric Surgery
Adesola C AkinkuotuOluyinka O Olutoye

Abstract

Attempts at defining predictors of poor outcome in fetal sacrococcygeal teratoma (SCT) have been hampered by small patient numbers. We sought to validate the utility of tumor volume to fetal weight ratio (TFR) as a predictor of poor prognosis and to identify other morphological outcome predictors in a multicenter series. Records of prenatally diagnosed SCT at three fetal centers from 1986 to 2011 were reviewed. Prenatal imaging characteristics including TFR, morphology, hydrops, and placentomegaly were assessed. Poor prognosis was defined as fetal demise, need for fetal intervention, or perinatal death. Receiver operating characteristic (ROC) analysis was used to select a TFR cutoff value. Seventy-nine fetuses with SCT were evaluated. Eleven pregnancies ending in elective termination were excluded. ROC analysis revealed that TFR >0.12 prior to 24 weeks gestation was predictive of poor prognosis (AUC=0.913; Sensitivity=91.7%, Specificity=76.2%, PPV=86.8%; NPV=84.2%). Solid tumor morphology and presence of hydrops were found to be predictors of poor prognosis. None of the factors associated with poor prognosis were independent predictors on multivariate analysis. This study validates TFR >0.12 prior to 24 weeks gestation as an ob...Continue Reading

References

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Citations

Apr 27, 2016·Pediatric Surgery International·Jose L PeiróAimen Shaaban
Aug 10, 2016·Journal of Pediatric Surgery·Marijke E B KremerL W Ernest van Heurn
Dec 30, 2017·Echocardiography·Luke Eckersley, Lisa K Hornberger
Feb 6, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Seung Mi LeeJong Kwan Jun
Aug 31, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·İdris Sertbaş, Mete Karatay
Mar 23, 2017·Paediatric Anaesthesia·Rebecca S IssermanElaina E Lin
Jan 4, 2020·Journal of Indian Association of Pediatric Surgeons·Devendra Kumar YadavPrabudh Goel
Mar 22, 2021·Journal of Pediatric Surgery·Hira AhmadJennifer H Aldrink
Mar 21, 2019·Fetal Diagnosis and Therapy·Christoph WohlmuthHelena M Gardiner

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