Predictors of positive blood cultures in critically ill patients: a retrospective evaluation.

Croatian Medical Journal
Marco PrevisdominiAndreas Perren

Abstract

To identify predictors of bacteremia in critically ill patients, to evaluate the impact of blood cultures on the outcome, and to define conditions for breakthrough bacteremia despite concurrent antibiotic treatment. A descriptive retrospective study was performed over a two-year period (2007-2008) in the medico-surgical Intensive Care Unit (ICU) of the San Giovanni Hospital in Bellinzona, Switzerland. Forty-five out of 231 patients (19.5%) had positive blood cultures. Predictors of positive blood cultures were elevated procalcitonin levels (>2 µg/L, P<0.001), higher severity scores (Simplified Acute Physiology Score II>43, P=0.014; Sequential Organ Failure Assessment >4.0, P<0.001), and liver failure (P=0.028). Patients with bacteremia had longer hospital stays (31 vs 21 days, P=0.058), but their mortality was not different from patients without bacteremia. Fever (t>38.5°C) only showed a trend toward a higher rate of blood culture positivity (P=0.053). The rate of positive blood cultures was not affected by concurrent antibiotic therapy. The prediction of positive blood culture results still remains a very difficult task. In our analysis, blood cultures were positive in 20% of ICU patients whose blood was cultured, and positive...Continue Reading

References

Jan 16, 1991·JAMA : the Journal of the American Medical Association·D W BatesT H Lee
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N RolandoR Williams
Jun 1, 1988·American Journal of Infection Control·P A GrossK A Reilly
Nov 1, 1987·Diagnostic Microbiology and Infectious Disease·R McKenzie, L G Reimer
Jul 1, 1994·Intensive Care Medicine·K J SchwenzerC G Durbin
May 25, 1994·JAMA : the Journal of the American Medical Association·D PittetR P Wenzel
Dec 22, 1993·JAMA : the Journal of the American Medical Association·J R Le GallF Saulnier
Dec 10, 1998·Journal of Internal Medicine·L LeiboviciS D Pitlik
Sep 2, 1999·Critical Care Medicine·J D EdgeworthS J Eykyn
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·B DigiovineM Higgins
Apr 17, 2001·Annals of Surgery·D P RaymondR G Sawyer
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C J GraceB Littenberg
Nov 12, 2002·Chest·Shirin Shafazand, Ann B Weinacker
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Mark L MeterskyPeter M Houck
Jun 25, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M S TabrizR Khatib
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F R CockerillW R Wilson
Jan 21, 2006·Critical Care Medicine·Jean-Louis VincentUNKNOWN Sepsis Occurrence in Acutely Ill Patients Investigators
May 23, 2008·Journal of Clinical Pathology·D J Unsworth
Sep 17, 2008·Swiss Medical Weekly·M StoeckleW Zimmerli
Feb 9, 2011·Scandinavian Journal of Infectious Diseases·Irma KoivulaAuni Juutilainen

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Citations

Jun 5, 2014·BMC Microbiology·Tomasz GosiewskiMałgorzata Bulanda
May 28, 2016·Clinics in Chest Medicine·Stefan Riedel, Karen C Carroll
Nov 26, 2015·PloS One·Cornelis H van WerkhovenMarc J M Bonten
Nov 5, 2016·American Journal of Infection Control·Daniel BrooksMalcolm G Booth
Dec 9, 2017·BMC Medical Informatics and Decision Making·Bernard HernandezPantelis Georgiou
Aug 2, 2019·Journal of Intensive Care·Cristhieni RodriguesTania Mara Varejão Strabelli
Jul 22, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Felipe Francisco TuonVictoria Stadler Tasca Ribeiro
Sep 9, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Gülsüm ÖzkanIlknur Erdem

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