Predictors of post-treatment stenosis in cervical esophageal cancer undergoing high-dose radiotherapy

World Journal of Gastroenterology : WJG
Jun Won KimIk Jae Lee

Abstract

To evaluate toxicity and treatment outcome of high-dose radiotherapy (RT) for cervical esophageal cancer (CEC). We reviewed a total of 62 consecutive patients who received definitive RT for stage I to III cervical esophageal cancer between 2001 and 2015. Patients who received < 45 Gy, treated for lesions below sternal notch, treated with palliative aim, treated with subsequent surgical resection, or diagnosed with synchronous hypopharyngeal cancer were excluded. Treatment failures were divided into local (occurring within the RT field), outfield-esophageal, and regional [occurring in regional lymph node(s)] failures. Factors predictive of esophageal stenosis requiring endoscopic dilation were analyzed. Grade 1, 2, and 3 esophagitis occurred in 19 (30.6%), 39 (62.9%), and 4 patients (6.5%), respectively, without grade ≥ 4 toxicities. Sixteen patients (25.8%) developed post-RT stenosis, of which 7 cases (43.8%) were malignant. Four patients (6.5%) developed tracheoesophageal fistula (TEF), of which 3 (75%) cases were malignant. Factors significantly correlated with post-RT stenosis were stage T3/4 (P = 0.001), complete circumference involvement (P < 0.0001), stenosis at diagnosis (P = 0.024), and endoscopic complete response (P =...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Nov 1, 1984·Southern Medical Journal·D J LeeH Kashima
Mar 1, 1981·The American Journal of Surgical Pathology·M Berthrong, L F Fajardo
Sep 7, 1999·International Journal of Radiation Oncology, Biology, Physics·P D MaguireL B Marks
Feb 17, 2001·The Journal of Pathology·J HandschelU Joos
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D MinskyDavid P Kelsen
Jun 28, 2005·Clinics in Plastic Surgery·Stuart ArchibaldAchilleas Thoma
Jul 15, 2005·Seminars in Oncology·Maria Werner-Wasik
Jun 19, 2009·Head & Neck·Allen M ChenJames A Purdy
Apr 12, 2011·International Journal of Radiation Oncology, Biology, Physics·Kazushige AtsumiHiroshi Honda
Oct 24, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E GkikaC Pöttgen
Mar 13, 2014·Head & Neck·G Daniel GrassAnand Sharma
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 28, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HoebenJ de Vos-Geelen

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