Predictors of Postoperative Diabetes Insipidus Following Endoscopic Resection of Pituitary Adenomas

Journal of the Endocrine Society
Pratima NayakLuma Ghalib

Abstract

The development of diabetes insipidus (DI) following transsphenoidal resection of pituitary adenomas has been associated with higher postsurgical morbidity and longer hospitalizations. Identifying these patients promptly and efficiently can lead to improved health care outcomes. We evaluated our institution's incidence of DI following pituitary adenoma resection and assessed for preoperative risk factors that were associated with postoperative DI. A retrospective review of 271 patients who underwent endoscopic endonasal resection of a pituitary adenoma between July 2010 and December 2016 by a single neurosurgical provider was completed. All cases were from a single-center, academic institution. Patients with a pituitary adenoma diagnosis confirmed on histology were included in the study. Those with previous surgery by a different provider were excluded. The incidence of DI at our institution was 16.6% (45 of 271 patients), with only 4% (11 patients) having permanent DI. The presence of visual abnormalities (CI 1.29 to 4.75), suprasellar extension (CI 1.36 to 6.88), and maximal tumor diameter (1.02 to 1.08) was significantly associated with an increased incidence of postoperative DI (P < 0.05). Hyperprolactinemia, tumor function...Continue Reading

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Citations

Sep 30, 2020·Pituitary·Friso de VriesNienke R Biermasz
Aug 4, 2020·Expert Review of Endocrinology & Metabolism·Kumar AbhinavLaurence Katznelson
Jan 8, 2021·Anesthesia and Analgesia·Lauren M Van DecarMolly B Kraus
Mar 2, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amporn VanasuntornChutintorn Sriphrapradang

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