Predictors of pregnancy outcome for infertile couples attending IVF and ICSI programmes

Andrologia
Z ZhangY-T Dai

Abstract

The purpose of this study was to evaluate the predictors of pregnancy outcome for infertile couples attending in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) programmes. Infertile couples attending IVF or ICSI procedures were included in this study. Related data including semen parameters and male and female age and body mass index were collected and analysed. The main outcome was clinical pregnancy, defined as an ultrasound detection of foetal heartbeat 6 weeks after embryo transfer. A total of 1316 couples who underwent IVF and 266 who underwent ICSI were recruited for this study. A multivariate logistic regression with likelihood ratio test revealed the following predictors of pregnancy outcome: female age and sperm DNA fragmentation index (DFI) and acrosomal activity in IVF procedures (chi-square of likelihood ratio = 26.42, d.f. = 3, P < 0.005) and female age and DFI in ICSI procedures (chi-square of likelihood ratio = 18.88, d.f. = 2, P < 0.005). In conclusion, our study indicated that sperm DFI, female age and acrosomal levels have a significant effect on ART pregnancy outcome.

References

Jan 1, 1988·Archives of Andrology·T F KrugerS Oehninger
Nov 1, 1993·Fertility and Sterility·R SharmaD R Bromham
Aug 1, 1997·Fertility and Sterility·A S Lim, M F Tsakok
Jun 7, 2000·Urology·F F PasqualottoA Agarwal
Dec 6, 2003·Reproductive Biomedicine Online·Ralf HenkelThinus F Kruger
Jan 11, 2005·Human Reproduction·M BenchaibJ F Guérin
Apr 2, 2005·Human Reproduction·C GnothG Freundl
Apr 6, 2006·Fertility and Sterility·Sergey I MoskovtsevJ Brendan M Mullen
May 27, 2006·Theriogenology·B A BallI Dobrinski
Jun 3, 2006·Reproductive Biomedicine Online·Donald Evenson, Regina Wixon
Jun 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·A J WyrobekD Evenson
Oct 21, 2006·Human Reproduction·T E SchmidA J Wyrobek
Jan 2, 2007·Fertility and Sterility·Steven D SpandorferZev Rosenwaks
Feb 6, 2007·Trends in Endocrinology and Metabolism : TEM·Frank J BroekmansBart C Fauser
Apr 12, 2007·Reproductive Biomedicine Online·Yves J R MénézoMoncef Benkhalifa
Jul 24, 2007·Fertility and Sterility·John A CollinsPeter N Schlegel
Jun 29, 2010·Human Reproduction Update·L L van LoenderslootF van der Veen
May 16, 2012·Fertility and Sterility·Vasiliki A MoragianniDavid A Ryley
Jun 15, 2012·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Deirdre L Zander-FoxMichelle Lane
Sep 11, 2012·Fertility and Sterility·Jessica D K KresowikBradley J Van Voorhis
Sep 13, 2012·Human Reproduction·Ronit MachtingerCatherine Racowsky
Sep 21, 2012·Methods in Molecular Biology·Donald P Evenson
Feb 9, 2013·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Nov 14, 2014·Journal of Assisted Reproduction and Genetics·Zheng ZhangYutian Dai
Apr 10, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John J ZhangZaher Merhi
Apr 22, 2015·Systems Biology in Reproductive Medicine·Barbara E SpeyerPaul Serhal

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