Predictors of premature discontinuation of treatment in multiple disease states.

Patient Preference and Adherence
Eric NantzVladimir Skljarevski

Abstract

Premature discontinuation of treatment impacts outcomes of clinical practice. The traditional perception has been patient discontinuation is mainly driven by unwanted side effects. Systematic analysis of data from clinical trials across several disease states was performed to identify predictors of premature discontinuation during clinical interventions. A post hoc analysis was conducted on 22 randomized, double-blind, placebo-controlled clinical trials for treatment of fibromyalgia, diabetic peripheral neuropathic pain, major depressive disorder, and generalized anxiety disorder. Analyses were conducted on pooled data within each disease state. Lack of early therapeutic response was a significant predictor of patient discontinuation in each disease state. Visit-wise changes in therapeutic response and severity of adverse events were also significant risk factors, with change in therapeutic response having a higher significance level in three disease states. Patients who discontinued due to adverse events had similar therapeutic responses as patients completing treatment. Contrary to the conventional belief that premature treatment discontinuation is primarily related to adverse events, our findings suggest lack of therapeutic ...Continue Reading

References

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Citations

Sep 22, 2011·ClinicoEconomics and Outcomes Research : CEOR·Xianchen LiuDouglas E Faries
Aug 7, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Monika SalgueiroJon Jatsu Azkue
Feb 19, 2013·General Hospital Psychiatry·Chi-Shin WuMei-Shu Lai
Apr 8, 2014·Atencion primaria·Ignacio Párraga MartínezUNKNOWN en representación del Grupo ADSCAMFYC
Aug 28, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Anat FisherNeena L Chappell
Dec 9, 2016·Expert Review of Pharmacoeconomics & Outcomes Research·Tracy L Skaer, Winghan Jacqueline Kwong
Aug 14, 2010·International Clinical Psychopharmacology·Xianchen LiuStephen L Able
Jun 28, 2015·The Patient·Kathryn A MartinezSarah T Hawley

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

MXSEV

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