Predictors of red blood cell transfusion and its association with prognosis in patients undergoing extracorporeal membrane oxygenation

The International Journal of Artificial Organs
Hugo Lo PintoNicolas Allou

Abstract

Few data are available on the potential benefits and risks of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation. The aim of this study was to identify the determinants and prognosis of red blood cell transfusion in patients undergoing extracorporeal membrane oxygenation, with a special focus on biological parameters during extracorporeal membrane oxygenation treatment. We conducted a single-center retrospective cohort study including all consecutive patients who underwent extracorporeal membrane oxygenation between January 2010 and December 2015. The 201 evaluated patients received a median of 0.9 [0.5-1.7] units of red blood cell per day. Significant and clinically relevant variables that best correlated with units of red blood cell transfused per day of extracorporeal membrane oxygenation were lower median daily prothrombin time in percentage (Quick) ( t = -0.016, p < 0.0001), higher median daily free bilirubin level ( t = 0.016, p < 0.0001), and lower pH ( t = -2.434, p < 0.0001). In multivariate analysis, red blood cell transfusion was associated with a significantly higher rate of in-intensive care unit mortality (per red blood cell unit increment; adjusted odds ratio: 1.07, 95% confiden...Continue Reading

References

Sep 24, 2002·JAMA : the Journal of the American Medical Association·Jean Louis VincentUNKNOWN ABC (Anemia and Blood Transfusion in Critical Care) Investigators
Oct 7, 2004·JAMA : the Journal of the American Medical Association·Sunil V RaoRobert M Califf
Oct 22, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Miguel Lebrón GallardoGuillermo Quesada García
Feb 8, 2006·Annals of Internal Medicine·Brendan M Reilly, Arthur T Evans
Oct 14, 2010·JAMA : the Journal of the American Medical Association·Ludhmila A HajjarJose O C Auler
Jul 28, 2011·Anesthesiology·Brian M GillissMichael A Gropper
Jan 4, 2013·The New England Journal of Medicine·Càndid VillanuevaCarlos Guarner
Jan 15, 2013·Annals of Intensive Care·Adrien BougléJacques Duranteau
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 19, 2013·The Journal of Thoracic and Cardiovascular Surgery·Damien J LaParUNKNOWN Investigators for the Virginia Cardiac Surgery Quality Initiative
Dec 17, 2014·The Annals of Thoracic Surgery·Cara L AgerstrandDaniel Brodie
Mar 12, 2015·The New England Journal of Medicine·Gavin J MurphyUNKNOWN TITRe2 Investigators
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Satoshi Gando, Yasuhiro Otomo
Aug 15, 2015·Intensive Care Medicine·Hye Ju YeoWoo Hyun Cho
Jun 21, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Helmuth TauberCorinna Velik-Salchner
Oct 8, 2016·Annals of Intensive Care·Cécile AubronZoe McQuilten
Oct 13, 2016·JAMA : the Journal of the American Medical Association·Jeffrey L CarsonAaron A R Tobian

❮ Previous
Next ❯

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.