Predictors of Red Cell Alloimmunization in Kurdish Multi Transfused Patients with Hemoglobinopathies in Iraq

Hemoglobin
Muqdad M N Al-MousawiRubad Alnaqshabandi

Abstract

Hemoglobinopathies are significant health problems in Iraq, including its Northern Kurdistan region. One of the essential components of management of these disorders is regular lifelong blood transfusions. The latter is associated with several complications including red cell alloimmunization. No study has looked at the frequency of alloimmunization and its associations in the country. To address the latter issue, 401 multi transfused patients [311 with β-thalassemia (β-thal) syndrome and 90 with sickle cell disease], registered at a large thalassemia care center in Iraqi Kurdistan had their records reviewed, and their sera tested for atypical antibodies using screening and extended red cell panels. Red cell alloimmunization was detected in 18 patients (4.5%) with a total of 20 alloantibodies, while no autoantibodies were detected. The most frequent alloantibody was anti-E, followed by anti-D, anti-K, anti-C(w), anti-C, anti-c and anti-Le(a). Ethnicity was an important predictor of alloimmunization, while age at start of transfusion (>2 vs. ≤2 years) (p = 0.005), Rhesus D (RhD) negative status (p = 0.0017) and history of previous transfusion reactions (p = 0.007) showed a statistically significant higher rate of alloimmunizatio...Continue Reading

References

Jan 1, 1990·Vox Sanguinis·T SpanosC Kattamis
May 27, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Murao, M B Viana
Dec 13, 2005·Annals of the New York Academy of Sciences·V S SakhalkarJ D Cotelingam
Sep 11, 2007·International Journal of Laboratory Hematology·M KarimiZ Davatolhagh
Oct 26, 2007·Transfusion·Martijn P BauerErnest Briët
Jan 8, 2008·Lancet·M D Cappellini, G Fiorelli
Jul 1, 2009·Asian Journal of Transfusion Science·Mohammad Hadi SadeghianMohammad Khajeh Daluei
Feb 18, 2011·British Journal of Haematology·Alexis A ThompsonUNKNOWN Thalassemia Clinical Research Network Investigators
May 9, 2012·Pediatric Blood & Cancer·Kim Smith-Whitley, Alexis A Thompson
Oct 5, 2012·British Journal of Haematology·Stella T ChouAlexis A Thompson
Dec 12, 2012·Journal of Community Genetics·Hanan A Hamamy, Nasir A S Al-Allawi
May 3, 2014·Archives of Pathology & Laboratory Medicine·Eiman HusseinAbeer Kamal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.