PMID: 9175022Jan 1, 1997Paper

Predictors of renal outcome in diffuse proliferative glomerulonephritis in systemic lupus erythematosus

Lupus
M MoscaS Bombardieri

Abstract

The occurrence of nephritis is considered to be the most important factor influencing the prognosis in systemic lupus erythematosus (SLE). Despite the apparent histological similarity of the lesions, however, patients with diffuse proliferative glomerulonephritis (DPGN) may exhibit different outcomes. A retrospective study was carried out on 81 SLE patients with DPGN to evaluate the prognostic significance of different clinical, serological and histological variables; in particular, 95 renal biopsies were re-evaluated and the activity and chronicity indices for the patients were determined. A positive correlation was observed between the presence of chronic lesions on renal biopsy and a poor renal outcome (< 0.001). Moreover, in the repeat biopsies the patients with a poor outcome showed a higher degree of chronic lesions. Active lesions and other clinical and serological parameters did not correlate with the outcome.

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Citations

Feb 14, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Neamatollah AtaeiMarzieh Haddadi
Mar 29, 2002·Kidney International·Marta MoscaStefano Bombardieri
Jul 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriëlle M N DaleboudtStefan P Berger
Nov 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria S StoenoiuUNKNOWN MAINTAIN Nephritis Trial Group
Jan 27, 2005·Journal of Paediatrics and Child Health·J J KhooC K Chin
Oct 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vladimir Tesar
Nov 15, 2014·Lupus Science & Medicine·G GreloniE R Soriano
Jan 12, 1999·Lupus·J P Grande, J E Balow
Mar 17, 2006·Lupus·C E H BarberJ G Hanly
Dec 28, 2018·European Journal of Clinical Investigation·Siwen GongManshu Sui
Jun 15, 2017·Medicine·Javier NarváezJoan Miquel Nolla
Jan 5, 2018·International Urology and Nephrology·Wei PengWei Qin
Apr 13, 2021·Indian Journal of Nephrology·Krishan L GuptaRitambhra Nada

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