Predictors of Residual Disease After Breast Conservation Surgery

Annals of Surgical Oncology
Lisa J Findlay-ShirrasMaged Nashed

Abstract

Breast-conserving therapy is the standard of care for early-stage breast cancer. In the era of multimodality therapy, the debate on the value of revision surgery for compromised margins continues, and high re-excision rates persist despite updated guidelines. Our study sought to identify the local re-excision rate for compromised margins after lumpectomy, and identify predictors of residual disease at re-excision. This population-based retrospective cohort study included women with breast cancer who underwent a lumpectomy between 2009 and 2012 in Manitoba, with close (≤ 2 mm) or positive margins that led to re-excision. Patient demographics and tumor characteristics were identified through provincial cancer registries and chart reviews. For patients with invasive cancer, the six anatomical margins were reported for margin status, width, and pathology type at the margin. Of the 2494 patients identified, 556 women underwent re-excision, yielding a re-excision rate of 22.29%. Of our 311 patients with invasive cancer who underwent re-excision, 62.7% had residual disease identified on revision. On univariable analysis, the size and grade of the invasive component, nodal stage, and the number of positive margins were associated with ...Continue Reading

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Citations

Oct 26, 2018·Annals of Surgical Oncology·Lisa J Findlay-Shirras, Maged Nashed
Apr 20, 2021·The American Surgeon·Catherine Sarre-LazcanoHeriberto Medina-Franco
Jul 31, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Duncan James SimpsonBrendan McFall
Jan 5, 2022·The American Surgeon·Ileana HorattasAnees B Chagpar

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