Predictors of Respiratory Decline Following Stereotactic Ablative Radiotherapy to Multiple Lung Tumors

Clinical Lung Cancer
Everett J ModingMichael F Gensheimer

Abstract

Stereotactic ablative radiotherapy (SABR) is highly effective at controlling early stage primary lung cancer and lung metastases. Although previous studies have suggested that treating multiple lung tumors with SABR is safe, post-treatment changes in respiratory function have not been analyzed in detail. We retrospectively identified patients with 2 or more primary lung cancers or lung metastases treated with SABR and analyzed clinical outcomes and predictors of toxicity. We defined a composite respiratory decline endpoint to include increased oxygen requirement, increased dyspnea scale, or death from respiratory failure not owing to disease progression. A total of 86 patients treated with SABR to 203 lung tumors were analyzed. A total of 21.8% and 41.8% of patients developed composite respiratory decline at 2 and 4 years, respectively. When accounting for intrathoracic disease progression, 12.7% of patients developed composite respiratory decline at 2 years. Of the patients, 7.9% experienced grade 2 or greater radiation pneumonitis. No patient- or treatment-related factor predicted development of respiratory decline. The median overall survival was 46.9 months, and the median progression-free survival was 14.8 months. The cumu...Continue Reading

Citations

May 10, 2020·Health Physics·Evagelia C LaiakisAlbert J Fornace
Apr 27, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Celion TangAhmed Salem

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