Predictors of response in a sample of treatment-resistant psychotic patients on clozapine

European Archives of Psychiatry and Clinical Neuroscience
A CiapparelliL Dell'Osso

Abstract

This study aims at identifying potential predictors of clinical response and functional outcome in 101 neuroleptic-refractory patients with a DSM-III-R diagnosis of schizophrenia (N = 34), schizoaffective disorder (N = 30) or bipolar disorder with psychotic features (N = 37), naturalistically treated with clozapine over a 48-month period. The "clinical response" and "functional outcome" criteria were respectively defined a priori as: a reduction of at least 50 % in the Brief Psychiatric Rating Scale total score in one evaluation with respect to baseline; and a Global Assessment of Functioning Scale score of at least 50. Several clinical and socio-demographic variables were assessed at baseline and only the diagnosis of bipolar disorder was significantly related with the clinical response. Variables significantly related with the functional outcome were female gender, university education and early age at onset.

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Citations

Aug 28, 2007·The Psychiatric Clinics of North America·Helio Elkis
Aug 8, 2007·Psychiatry Research·Judith UsallUNKNOWN SOHO Study Group
Jun 20, 2015·Frontiers in Endocrinology·Megan Elizabeth Rich, Heather Kingsley Caldwell
Jan 29, 2017·Expert Opinion on Pharmacotherapy·Bettina LangeJ Malte Bumb
Feb 23, 2017·Journal of Clinical Psychopharmacology·Ole Köhler-ForsbergChristiane Gasse
Aug 21, 2019·European Archives of Psychiatry and Clinical Neuroscience·Parita ShahAriel Graff-Guerrero
Dec 25, 2007·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Helio Elkis, Herbert Y Meltzer
Dec 3, 2020·Neuropsychiatric Disease and Treatment·Wenying YiYuping Ning

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