Abstract
4-Aminopyridine (4AP), a potassium channel antagonist, can improve hindlimb motor function in dogs with chronic thoracolumbar spinal cord injury (SCI); however, individual response is variable. We hypothesized that injury characteristics would differ between dogs that do and do not respond to 4AP. Our objective was to compare clinical, electrodiagnostic, gait, and imaging variables between dogs that do and do not respond to 4AP, to identify predictors of response. Thirty-four dogs with permanent deficits after acute thoracolumbar SCI were enrolled. Spasticity, motor and sensory evoked potentials (MEPs, SEPs), H-reflex, F-waves, gait scores, and magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) were evaluated at baseline and after 4AP administration. Baseline variables were assessed as predictors of response; response was defined as ≥1 point change in open field gait score. Variables were compared pre- and post-4AP to evaluate 4AP effects. Fifteen of 33 (45%) dogs were responders, 18/33 (55%) were non-responders and 1 was eliminated because of an adverse event. Pre-H-reflex threshold <1.2 mA predicted non-response; pre-H-reflex threshold >1.2 mA and Canine Spasticity Scale overall score <7 were predictive of r...Continue Reading
References
Apr 1, 1978·Journal of Comparative Pathology·I R Griffiths
Jan 1, 1991·Journal of Neurotrauma·A R BlightW R Widmer
Jan 1, 1989·Brain Research Bulletin·A R Blight
May 20, 1982·Brain Research·E JankowskaE Sykova
Feb 7, 1980·Nature·R M SherrattT A Sears
Aug 1, 1994·Journal of Neurotrauma·K C HayesA R Blight
Jan 1, 1993·Journal of Neurotrauma·R R HanseboutK Reddy
Jan 1, 1993·Veterinary Surgery : VS·A M SylvestreG D Partlow
Apr 1, 1993·Paraplegia·K C HayesJ T Hamilton
Jun 1, 1996·Experimental Neurology·D M BassoJ C Bresnahan
Mar 1, 1997·Journal of Neurotrauma·J QiaoG A Delaney
Apr 1, 1997·Journal of Neurotrauma·K C Hayes, B A Kakulas
Nov 14, 1998·Journal of Neurotrauma·P J PotterD Mason
Dec 28, 1999·Brain : a Journal of Neurology·K J SmithG R John
Aug 31, 2001·Journal of Neurotrauma·D L WolfeP J Potter
Oct 11, 2001·American Journal of Veterinary Research·N J OlbyB W Keene
Feb 18, 2005·Journal of Neurotrauma·Guido C KoopmansElbert A J Joosten
Jun 14, 2006·Brain Pathology·Peter M Smith, Nick D Jeffery
Sep 17, 2009·Journal of Veterinary Pharmacology and Therapeutics·N J OlbyM Papich
Dec 21, 2010·Archives of Medical Research·Israel GrijalvaIgnacio Madrazo
Nov 22, 2012·Brain : a Journal of Neurology·Nicolas GrangerNick D Jeffery
Nov 13, 2013·Spinal Cord·D D CardenasA R Blight
Mar 7, 2014·BMC Veterinary Research·Natasha J OlbyAudrey Muguet-Chanoit
Jan 1, 2015·PloS One·Ji-Hey LimNatasha J Olby
Feb 17, 2015·Clinical Neurology and Neurosurgery·Byron A Kakulas, Cahyono Kaelan
Nov 2, 2015·Journal of Veterinary Internal Medicine·N J OlbyK R Muñana
May 4, 2017·Journal of Neurotrauma·Melissa J LewisNatasha J Olby
Jun 27, 2017·American Journal of Veterinary Research·Melissa J Lewis, Natasha J Olby
Oct 5, 2017·Journal of Neurotrauma·Melissa J LewisNatasha J Olby
Oct 24, 2017·Spinal Cord·Melissa J LewisNatasha J Olby
Citations
Aug 26, 2020·Journal of Neurotrauma·Zachary F StielperNicholas W Gilpin
Jan 11, 2020·Scientific Reports·Sofia Rodríguez-RangelJorge E Sánchez-Rodríguez
Oct 17, 2020·Frontiers in Veterinary Science·Melissa J LewisUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)
Nov 17, 2020·Frontiers in Veterinary Science·Melissa J LewisUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Ângela MartinsAntónio Ferreira