Predictors of response to combined wake and light therapy in treatment-resistant inpatients with depression

Chronobiology International
Mette KraghPoul Videbech

Abstract

There is growing evidence for combined chronotherapeutic interventions as adjunctive treatments for major depression. However, as the treatments can be demanding, we need to identify predictors of response. This study aimed to describe predictors of response, remission and deterioration in the short-term phase, as well as predictors of long-term response. The predictors investigated were gender, type of depression, severity of depression, treatment resistance, quetiapine use, general self-efficacy, educational level and positive diurnal variation. Follow-up data from 27 inpatients with moderate-to-severe depression participating in a chronotherapeutic intervention were analysed. As a supplement to standard treatment, they completed 3 wake therapy sessions in the first week, 30 min daily light treatment and sleep-time stabilisation in the entire 9-week study period. Patients had a significant decrease of depressive symptoms during the first 6 days measured by HAM-D6. At Day 6, 41% of the patients responded to the treatment and 19% fulfilled the criteria of remission. Deterioration by the end of wake therapy sessions was however not uncommon. In the short-term phase, mild degree of treatment resistance was associated with remissi...Continue Reading

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Citations

Nov 22, 2018·Nature Reviews. Neuroscience·Ryan W Logan, Colleen A McClung
Oct 14, 2019·Journal of Affective Disorders·Clara HumpstonDavid Veale
Feb 20, 2021·Journal of Affective Disorders·Laura D YuenDavid J Hellerstein
Dec 24, 2020·The Australian and New Zealand Journal of Psychiatry·Gin S MalhiGreg Murray

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