Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema

Chest
Dirk-Jan SlebosRENEW Study Group

Abstract

The Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) trial reported improvements in quality of life, pulmonary function, and exercise performance following endobronchial coil treatment. The purpose of this post hoc analysis was to identify baseline predictors, including quantitative CT measures, that identify patients most likely to significantly benefit from endobronchial coil therapy. Quantitative CT analysis by an independent radiology laboratory and a qualitative evaluation by five blinded experts of the baseline thoracic CT imaging were performed. Univariate and multivariate logistic regression analyses were performed to elucidate characteristics associated with clinical response. In total, 125 patients underwent coil treatment and had evaluable 12-month follow-up results. Of these, 78 patients received treatment of lobes with the highest emphysematous destruction determined by quantitative CT analysis (quantitative visual match [QVM]+), and 47 received treatment in at least one lobe that was not the most destroyed (QVM-). From the 78 patients with QVM+ treatment, a subgroup of 50 patients (64%) was identified with baseline residual volume > 200% predicted, emphysema score > 20% low attenuation area,...Continue Reading

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Citations

May 6, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Jorrit B A WellingDirk-Jan Slebos
Feb 6, 2020·American Journal of Respiratory and Critical Care Medicine·Gerard J CrinerFelix J Herth
May 21, 2020·Seminars in Respiratory and Critical Care Medicine·Justin L Garner, Pallav L Shah
Mar 3, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Jeanne Marie PerotinGaëtan Deslee
May 8, 2021·Interactive Cardiovascular and Thoracic Surgery·Sebastian MangPhilipp M Lepper
Dec 18, 2019·Respiration; International Review of Thoracic Diseases·Leonie BienerCarmen Pizarro
Jan 23, 2020·Respiration; International Review of Thoracic Diseases·Justin L GarnerPallav L Shah

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