Predictors of response to extracorporeal photopheresis in advanced mycosis fungoides and Sézary syndrome.

Photodermatology, Photoimmunology & Photomedicine
Laura Y McGirtE C Vonderheid

Abstract

Extracorporeal photopheresis (ECP) has been utilized for more than 20 years to treat cutaneous T-cell lymphoma (CTCL), but a clinical response can take up to 9 months to manifest. This study was undertaken to determine whether clinical features, laboratory values, cytokine levels, or gene expression levels of tumor markers are useful to predict the subsequent response to ECP in CTCL patients with blood involvement. Twenty-one patients with CTCL treated with ECP as monotherapy for at least 6 months were retrospectively identified. Laboratory and clinical data and blood obtained at baseline, 3, and 6 months of treatment were used for analysis. In pretreatment blood specimens, a lower percentage of Sézary cells and a higher absolute eosinophil count were associated with a favorable clinical response. Clinical evidence of an early response after 3 months of ECP did not reliably predict a favorable response at 6 months or beyond. Comparison of cytokines, gene transcripts, and other laboratory measures of disease did not correlate with the subsequent clinical response, although lactate dehydrogenase levels tended to decrease progressively in ECP-responsive cases and increase progressively in ECP-non-responsive cases. Additionally, se...Continue Reading

References

Sep 1, 1992·Journal of the American Academy of Dermatology·P HealdR Edelson
Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Dec 1, 1996·Journal of the American Academy of Dermatology·J A ZicL E King
Mar 5, 1998·Journal of the American Academy of Dermatology·E C VonderheidM A Wasik
Nov 30, 1999·Photodermatology, Photoimmunology & Photomedicine·S B JiangH W Lim
Jan 10, 2001·Journal of the American Academy of Dermatology·U WollinaM Kaatz
Sep 21, 2001·The Journal of Investigative Dermatology·E C VonderheidM Polansky
Oct 12, 2001·Annals of the New York Academy of Sciences·C L BergerR Edelson
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·P ShashkinK Ley
Jun 5, 2003·The Journal of Experimental Medicine·Laszlo KariLouise C Showe
Jul 25, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·F Heshmati
Sep 6, 2003·Journal of Cutaneous Medicine and Surgery·Madeleine DuvicRakhshandra Talpur
Apr 21, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·A DarvayR Russell-Jones
Sep 24, 2004·Archives of Dermatology·Emmanuelle Tancrède-BohinPatrice Morel
Sep 25, 2004·Journal of the American Academy of Dermatology·Amy E AdamsThomas S Kupper
Apr 21, 2005·The Journal of Clinical Investigation·Ellen J KimAlain H Rook
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira MaedaThomas Schwarz
Jul 16, 2005·Journal of the American Academy of Dermatology·Adriana SchmidtJohn Zic
Jul 21, 2005·The British Journal of Dermatology·S DalleL Thomas
Sep 9, 2005·Pediatric Research·Maria Karlsson FaresjöJohnny Ludvigsson
Jun 3, 2006·The Journal of Investigative Dermatology·Machteld M TiemessenSusan John
Sep 22, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·V RaoT Moen
Feb 1, 2007·The British Journal of Dermatology·J N DauendorfferH Bachelez
Oct 24, 2007·Critical Reviews in Oncology/hematology·Pier Luigi ZinzaniLorenzo Cerroni
Jan 18, 2008·The Journal of Investigative Dermatology·Marloes S van KesterMaarten H Vermeer
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin F ChongHenry K Wong
Mar 13, 2008·American Journal of Hematology·Aleksandar M Babic
Mar 18, 2008·Lancet·Sam T HwangWyndham H Wilson

❮ Previous
Next ❯

Citations

Jul 19, 2014·The Journal of Dermatological Treatment·Crystal AgiGinette Hinds
Jan 21, 2014·Journal of the American Academy of Dermatology·Sarah I JawedChristiane Querfeld
Oct 17, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Franz Trautinger
Dec 21, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·R KnoblerU Hillen
Jan 9, 2018·Leukemia & Lymphoma·Jenna JanigaFarah Abdulla
Dec 2, 2017·The Journal of Dermatological Treatment·Larisa Geskin, Daniel C Malone
May 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Neha Mehta-ShahYoun H Kim
Oct 8, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·R KnoblerH Greinix
Jun 10, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·L Y McGirtC M Eischen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.