PMID: 15230667Jul 3, 2004Paper

Predictors of response to infliximab in patients with fistulizing Crohn's disease

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
M Luna-ChadidJ Maté Jiménez

Abstract

To evaluate the efficacy and toxicity of infliximab for the treatment of fistulizing Crohn's disease. Consecutive patients with fistulizing Crohn's disease receiving infliximab were prospectively enrolled. Partial response was defined as a reduction of 50% or more from base-line in the number of draining fistulae. Complete response was defined as the closure of all fistulae. The influence of different variables on the efficacy of infliximab was evaluated. 108 patients were included. The disease was inflammatory plus fistulizing in 18% and only fistulizing in 82%. After the third infusion of infliximab the response was partial in 26% and complete in 57%. Response (%) rates (partial/complete) depending on fistula location were: enterocutaneous (25/68%), perianal (35/60%), rectovaginal (36/64%), and enterovesical (20/40%). None of the studied variables (including concomitant immunosuppressive therapy) correlated with efficacy of infliximab in the multivariate analysis. Incidence of adverse effects (21%) depending on the dose of infliximab was: first dose (5.6%), second (7.4%), and third (11.1%). Infliximab is an efficacious treatment for fistulizing Crohn's disease. Partial response was achieved in approximately one third of the p...Continue Reading

Citations

Oct 16, 2007·Digestive Diseases and Sciences·Stephen J RudolphRobert P McCabe
Aug 26, 2014·Alimentary Pharmacology & Therapeutics·C Dupont-LucasF M Ruemmele
Jan 27, 2007·Journal of Pediatric Gastroenterology and Nutrition·Jonathan E TeitelbaumFrederic Daum
Feb 28, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E Joline de GroofChristianne J Buskens
Dec 18, 2014·Journal of Crohn's & Colitis·Sumant InamdarKeith Sultan
Jun 24, 2017·Techniques in Coloproctology·G C BraithwaiteS R Brown
Jan 29, 2009·The American Journal of Gastroenterology·Javier P Gisbert, Julián Panés
Jul 29, 2016·Journal of Clinical Gastroenterology·Pavlos KaimakliotisParis P Tekkis
Apr 17, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Sudheer K VuyyuruVineet Ahuja
Feb 4, 2010·Gastroenterología y hepatología·Yago González-LamaLluís Abreu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved