Predictors of revision, prosthetic joint infection and mortality following total hip or total knee arthroplasty in patients with rheumatoid arthritis: a nationwide cohort study using Danish healthcare registers

Annals of the Rheumatic Diseases
Rene Lindholm CordtzLene Dreyer

Abstract

To investigate predictors of 10-year risk of revision and 1-year risk of prosthetic joint infection (PJI) and death following total hip/total knee arthroplasty (THA/TKA) in (1) patients with rheumatoid arthritis (RA) compared with patients with osteoarthritis (OA); and (2) patients with RA treated with biological disease-modifying antirheumatic drugs (bDMARD) within 90 days preceding surgery compared with non-treated. Register-based cohort study using the Danish National Patient Register, the DANBIO rheumatology register (RA-specific confounders and treatment episodes) and the Danish Hip and Knee Arthroplasty Registers. Survival analyses were used to calculate confounder-adjusted sub-HRs (SHR) and HRs. In total, 3913 patients with RA with THA/TKA were compared with 120 499 patients with OA. Patients with RA had decreased risk of revision (SHR 0.71 (0.57-0.89)), but increased risk of PJI (SHR=1.46 (1.13-1.88)) and death (HR=1.25 (1.01-1.55)). In DANBIO, 345 of 1946 patients with RA with THA/TKA had received bDMARD treatment within 90 days preceding surgery. bDMARD-treated patients did not have a statistically significant increased risk of revision (SHR=1.49 (0.65-3.40)), PJI (SHR=1.61 (0.70-3.69)) nor death (HR=0.75 (0.24-2.33))...Continue Reading

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Citations

Nov 5, 2019·Annals of Internal Medicine·Michael D GeorgeJeffrey R Curtis
Mar 29, 2019·Current Opinion in Rheumatology·Michael D George, Joshua F Baker
May 21, 2019·Annals of Internal Medicine·Bheeshma Ravi, Gillian Hawker
Oct 15, 2019·Arthritis Care & Research·Susan M GoodmanDana E Orange
Jul 17, 2020·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Haley KittleMark H Gonzalez
Sep 8, 2018·Zeitschrift für Rheumatologie·J Holinka
Jul 4, 2020·The Journal of Bone and Joint Surgery. American Volume·George A KomnosJavad Parvizi
Jun 6, 2021·The Journal of Arthroplasty·Elizabeth B GausdenMatthew P Abdel
Jul 17, 2021·Current Pain and Headache Reports·Kristen MathiasAlaa Abd-Elsayed

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