Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy

Seizure : the Journal of the British Epilepsy Association
Hai-Jiao WangLing Liu

Abstract

To evaluate the predictors of seizure reduction outcome after vagus nerve stimulation (VNS) in patients with drug-resistant epilepsy (DRE). A meta-analysis was performed using relevant research from databases such as PubMed, Embase, Cochrane Online Library, and Clinicaltrials.gov. Studies were selected according to predefined inclusion and exclusion criteria. The quality of studies was evaluated by using the Newcastle-Ottawa Scale (NOS) scale. All data was pooled by STATA 12.0 software for meta-analysis. The review considered 1281 articles, and 16 articles with NOS score ≥6 were included in the analysis. The meta-analysis showed that at 6 m, 1, 2, 3, 4, 6 and 12 years after implantation, 33.99, 43.42, 46.50, 63.31, 52.71, 54.64, 70.37 and 82.90% of patients exhibited >50% reduction of seizure frequency after VNS. The duration of epilepsy showed a significant difference between the good responders and poor responders (p = 0.038), whereas age at VNS implantation (p = 0.305), age at seizure onset (p = 0.530), seizure type (p = 0.11), etiology (p = 0.187), and history of previous epilepsy surgery (p = 0.075) were not predictors of seizure reduction outcome after VNS. Several features about the electroencephalogram (EEG) feature and...Continue Reading

Citations

Aug 26, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Toni KuljuJukka Peltola
Aug 31, 2020·Epilepsia·Adriana M WorkewychGeorge M Ibrahim
Aug 28, 2020·International Journal of Environmental Research and Public Health·Carlo Efisio MarrasNelia Zamponi

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