Predictors of surgical sperm retrieval in non-obstructive azoospermia: summary of current literature.

International Urology and Nephrology
Muhammad A ArshadSandro C Esteves

Abstract

Intracytoplasmic sperm injection (ICSI), combined with surgical sperm retrieval (SR) techniques, is the sole option for patients with non-obstructive azoospermia to achieve fertility; however, with suboptimal results. Given the variability in clinical presentation, the potential role of factors that can predict the likelihood of successful testicular SR needs to be clarified. This article summarizes the current evidence concerning the variables predicting SR success in non-obstructive azoospermic patients with spermatogenic failure. For this, we used 60 articles, including 46 original papers and six meta-analyses. Clinical and laboratory factors, as well as adjuvant therapies and surgical retrieval methods, were the factors most commonly investigated. We found that Klinefelter syndrome, Y chromosome microdeletions in regions AZFa/b, and Sertoli cell-only histopathology were associated with reduced SR success. By contrast, testis volume > 12.5 ml, history of cryptorchidism, use of micro-TESE as the sperm retrieval method, and adjuvant therapy were associated with improved SR success. None of the predictors, alone or combined, provide definitive information about the chances of harvesting sperm in men with non-obstructive azoospe...Continue Reading

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Citations

Jun 13, 2020·International Urology and Nephrology·Giovanni M Colpi, Ettore Caroppo
Jan 23, 2021·Problemy e̊ndokrinologii·M V Vorontsova, N Yu Kalinchenko
Jun 5, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Anna LyCharlotte Dupont
Jul 25, 2021·Journal of Clinical Medicine·Danilo L AndradeSandro C Esteves

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