Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Antonella AntenoraAlessandro Filla

Abstract

One hundred-eighteen spinocerebellar ataxia type 2 patients from 35 distinct families personally observed between 1973 and 2016 were retrospectively reviewed. The time point of data collection was 1 January 2017. Thirty-one patients were confined to wheelchair. The median time to wheelchair was 21 years (95% CI, 17.5-24.6). Thirty-seven patients were deceased. The median time to death was 25 years (95% CI, 22.9-27.1). CAG repeat number and ataxia score at first visit influenced the time to wheelchair and death.

References

May 13, 1998·Brain : a Journal of Neurology·T KlockgetherJ Dichgans
Jul 5, 2012·Clinical Genetics·L E Almaguer-MederosL Velásquez Pérez
Sep 15, 2017·Annals of Clinical and Translational Neurology·Antonella AntenoraAlessandro Filla
Mar 20, 2018·Lancet Neurology·Alhassane DialloSophie Tezenas du Montcel

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Citations

Jun 19, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Alhassane DialloSophie Tezenas du Montcel
Aug 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Polina A Egorova, Ilya B Bezprozvanny
Jan 26, 2020·The Cerebellum·Luis Velázquez-PérezUNKNOWN Cuban Hereditary Ataxias Network
Jul 22, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Friedemann BenderLudger Schöls

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