Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study

Kidney International
L G HunsickerP E Teschan

Abstract

The Modification of Diet in Renal Disease (MDRD) Study examined the effects of dietary protein restriction and strict blood pressure control on the decline in glomerular filtration rate (GFR) in 840 patients with diverse renal diseases. We describe a systematic analysis to determine baseline factors that predict the decline in GFR, or which alter the efficacy of the diet or blood pressure interventions. Univariate analysis identified 18 of 41 investigated baseline factors as significant (P < 0.05) predictors of GFR decline. In multivariate analysis, six factors--greater urine protein excretion, diagnosis of polycystic kidney disease (PKD), lower serum transferrin, higher mean arterial pressure, black race, and lower serum HDL cholesterol--independently predicted a faster decline in GFR. Together with the study interventions, these six factors accounted for 34.5% and 33.9% of the variance between patients in GFR slopes in Studies A and B, respectively, with proteinuria and PKD playing the predominant role. The mean rate of GFR decline was not significantly related to baseline GFR, suggesting an approximately linear mean GFR decline as renal disease progresses. The 41 baseline predictors were also assessed for their interactions ...Continue Reading

References

Jan 1, 1977·Kidney International·W E RutherfordJ D Vavra
Oct 1, 1992·Statistics in Medicine·M D Schluchter
Nov 1, 1991·Kidney International·S R SmithV W Dennis
May 1, 1990·Kidney International·M Walser
Jan 1, 1990·American Journal of Nephrology·J S Cameron
Feb 1, 1989·Kidney International·P C BrazyJ F Fitzwilliam
Sep 1, 1989·Journal of Internal Medicine·P StenvinkelJ Bergström
Mar 16, 1989·The New England Journal of Medicine·S G RostandH P Dustan
Dec 1, 1988·Kidney International·M Walser, L Ward
Jan 1, 1985·Kidney International·B J MaroniW E Mitch
Apr 15, 1983·Journal of Immunological Methods·R E Chambers, J T Whicher
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S R Silbiger, J Neugarten
Apr 1, 1993·Annals of Emergency Medicine·T W LukensD Effron
Apr 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J M FlackP Esunge
May 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A S LeveyP E Teschan

❮ Previous
Next ❯

Citations

Nov 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan L FurthUNKNOWN Kidney and Urology Foundation of America
Mar 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Jun 19, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cristina M Bouissou SoaresEduardo A Oliveira
Feb 5, 2013·The International Journal of Cardiovascular Imaging·Pawel BurchardtAnna Palasz
Mar 25, 2005·International Urology and Nephrology·Hippocrates Yatzidis
Apr 4, 2008·International Urology and Nephrology·Hulya TaskapanDimitrios G Oreopoulos
Nov 28, 2008·International Urology and Nephrology·Krishnaswamy Sampathkumar
Mar 6, 2008·Internal and Emergency Medicine·Takahiko NakagawaRichard J Johnson
Mar 20, 2003·Current Diabetes Reports·Robert D Toto
Feb 10, 2012·Current Hypertension Reports·Rikki M TannerPaul Muntner
Sep 12, 2000·Current Hypertension Reports·L D Dworkin, D G Shemin
Sep 12, 2000·Current Hypertension Reports·S C Textor, V J Canzanello
Aug 5, 2006·The American Journal of Medicine·Ja-Liang LinYen-Lin Huang
May 6, 2008·Journal of Feline Medicine and Surgery·Joanna D WhiteRichard Malik
May 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lee A HebertSaulo Klahr
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tobias KurthJ Michael Gaziano
Aug 15, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xueying Zhao
Feb 21, 2008·Nature Clinical Practice. Nephrology·Devasmita Choudhury, Cynthia Luna-Salazar
May 5, 2010·Nature Reviews. Nephrology·John C RutledgeDennis W Wilson
Aug 8, 2001·Journal of Internal Medicine·L G Gøransson, H Bergrem
Dec 5, 1998·Kidney International. Supplement·P Zucchelli, A Zuccalá
Jul 21, 1999·Kidney International. Supplement·P O AttmanO Samuelsson
Jan 5, 2000·Kidney International·B J Pereira
Mar 22, 2001·Kidney International·L A HebertB H Rovin
Aug 8, 2002·Kidney International·Maarten A M JansenUNKNOWN NECOSAD Study Group
Oct 9, 2003·Kidney International·Arjang DjamaliBryan N Becker
Mar 13, 2003·Kidney International·William F KeaneUNKNOWN RENAAL Study Investigators
Oct 9, 2003·Kidney International. Supplement·Madhumathi Rao, Brian J G Pereira
Jan 20, 2004·Advances in Renal Replacement Therapy·Thomas H Hostetter
Jan 20, 2004·Advances in Renal Replacement Therapy·Jay Lakkis, Matthew R Weir
Jan 24, 2003·The New England Journal of Medicine·Ja-Liang LinChun-Chen Yu
Nov 12, 2013·The New England Journal of Medicine·Afshin ParsaUNKNOWN CRIC Study Investigators
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Oct 1, 2011·Rejuvenation Research·Sandra V GiannelliJack Guralnik
Mar 1, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Erik M StuvelingDick de Zeeuw
Oct 15, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Manuel Praga
Mar 18, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sita GourishankarNeesh Pannu
Oct 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cristina M SoaresEduardo A Oliveira
Aug 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Britt B NewsomeWilliam M McClellan
Jul 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laurie A TomlinsonChakravarthi Rajkumar
Sep 19, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Victor LorenzoArmando Torres
May 27, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Loretta CainKyle Steenland
May 22, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nosratola D VaziriBernardo Rodriguez-Iturbe
Sep 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas StoycheffLesley A Stevens
Jan 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Colin D ChueCharles J Ferro
Sep 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barry R JohnsSun H Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.