Predictors of the rate of change in disease activity over time in LUMINA, a multiethnic US cohort of patients with systemic lupus erythematosus: LUMINA LXX.

Lupus
Jie ZhangG S Alarcón

Abstract

The objectives of the present study were (1) to clarify and quantify the relationship between age and disease duration with the rate of change in disease activity over time in patients with systemic lupus erythematosus (SLE) and (2) to explore other possible factors associated with this rate of change. To this end, SLE patients from LUMINA were studied if they had at least three visits in which disease activity (Systemic Lupus Activity Measure-Revised [SLAM-R]) had been ascertained. Variables associated with the rate (slope) of change in disease activity (obtained by regressing the SLAM-R score against the length of time from diagnosis to visit date) were examined by univariable and multivariable analyses. Five hundred and forty two of the 632 patients had at least three SLAM-R score. In multivariable analyses, Whites exhibited the fastest decline in disease activity, Texan Hispanics exhibited the slowest, trailed by the African Americans. Longer disease duration and HLA-DRB1*1503 positivity were associated with a slower decline whereas a greater number of American College of Rheumatology criteria and abnormal laboratory parameters (white blood cell counts, hematocrit and serum creatinine) were associated with a faster decline....Continue Reading

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Mar 1, 1996·Medicine·C DrenkardD Alarcón-Segovia
Jun 12, 1999·Arthritis and Rheumatism·C C MokC S Lau
Jan 1, 2000·Arthritis and Rheumatism·S G BarrM Petri
Jan 4, 2001·Rheumatology·M J MirzayanT Witte
Jan 5, 2002·Arthritis and Rheumatism·G S AlarcónUNKNOWN LUMINA Study Group. Lupus in Minority Populations, Nature versus Nurture
Aug 15, 2006·Annals of the Rheumatic Diseases·G S AlarcónUNKNOWN LUMINA Study Group

❮ Previous
Next ❯

Citations

Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·Anna Nuttall, David A Isenberg
Jan 8, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Martin AringerMin Ae Lee-Kirsch
Mar 19, 2014·Rheumatology·Mercedes A GarcíaUNKNOWN Grupo Latino Americano de Estudio del Lupus Eritematoso (GLADEL)
Aug 13, 2011·Expert Review of Pharmacoeconomics & Outcomes Research·Vibeke Strand, Alvina D Chu
Jan 3, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·João Furtado, David A Isenberg
Jul 29, 2011·Reumatología clinica·Graciela S Alarcón
May 7, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·João Furtado, David A Isenberg
May 9, 2012·Pediatric Clinics of North America·Jay Mehta
May 5, 2017·Expert Review of Clinical Immunology·Guillermo J Pons-EstelGraciela S Alarcón
Sep 17, 2018·The Journal of Rheumatology·Christine A PeschkenUNKNOWN CaNIOS 1000 Faces Investigators
Sep 12, 2019·Arthritis Care & Research·Hakan BabaoğluMichelle Petri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.