Predictors of Time to Discontinuation of Levodopa-Carbidopa Intestinal Gel Infusion: A Retrospective Cohort Study.

Journal of Parkinson's Disease
Harmen R MoesTeus van Laar

Abstract

Continuous intra-duodenal infusion of levodopa-carbidopa intestinal gel (LCIG) is a well-established therapy for patients with advanced Parkinson's disease (PD) suffering from motor complications despite optimized treatment with oral dopaminomimetics. However, time to discontinuation of treatment with LCIG varies considerably between patients, ranging from a few months to more than ten years. To improve the selection of candidates for LCIG, knowledge of prognostic factors is of paramount importance. To explore baseline predictors of time to discontinuation of LCIG. In this two-center retrospective cohort study, we reviewed the medical files of 98 PD patients treated with LCIG between April 2006 and December 2015 (53% male; mean age: 66.2 years; mean disease duration: 12.3 years). Baseline patient characteristics were used as covariates in Cox regression models. During follow-up (mean observation time: 2.6 years; range: 0.1-9.3) eighteen patients discontinued treatment (18.4%), while seven patients died (7.1%). Median duration of treatment with LCIG, estimated with Kaplan-Meier analysis, was 7.8 years (95% CI: 6.7-9.0). Disease duration (in years) at baseline was a statistically significant predictor of time to discontinuation o...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·N SyedJ I Sage
Aug 14, 1998·BMJ : British Medical Journal·D G Altman, J M Bland
Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J E Ahlskog, M D Muenter
Jun 5, 2003·Clinical Neuropharmacology·Dag NyholmSten-Magnus Aquilonius
Sep 11, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H Fox, Anthony E Lang
Feb 25, 2009·BMJ : British Medical Journal·Karel G M MoonsDouglas G Altman
Mar 3, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·David Devos, UNKNOWN French DUODOPA Study Group
Oct 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Iria Cabo LópezVicenta Sánchez Bernardos
Oct 21, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Anne Marthe MeppelinkKlaus Leonhard Leenders
Mar 1, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D NyholmA Johansson
Jul 17, 2013·BMC Medical Research Methodology·Lehana ThabaneCharles H Goldsmith
Dec 10, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M ZibettiL Lopiano
Dec 30, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Hubert H FernandezAlberto J Espay
Mar 27, 2015·Neurology·Daniela CalandrellaAlberto Albanese
Dec 24, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Anthony E LangJordan Dubow
Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Fabian KlostermannFelicitas Ehlen
Feb 28, 2017·Parkinsonism & Related Disorders·Mariachiara SensiUNKNOWN ITALIAN LEVODOPA CARBIDOPA INTESTINAL GEL WORKING GROUP
Dec 16, 2017·Movement Disorders Clinical Practice·David G StandaertJanet Benesh
Mar 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Hubert H FernandezAlberto J Espay

❮ Previous
Next ❯

Citations

Apr 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Taiji TsunemiNobutaka Hattori

❮ Previous
Next ❯

Software Mentioned

STATA
SPSS Statistics
Survival
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved