Predictors of tumor shrinkage after primary therapy with somatostatin analogs in acromegaly: a prospective study in 99 patients

The Journal of Clinical Endocrinology and Metabolism
Annamaria ColaoGaetano Lombardi

Abstract

Primary treatment with depot octreotide and lanreotide induces tumor shrinkage in newly diagnosed patients with acromegaly. The objective of the study was to evaluate clinical predictors of tumor shrinkage. This was an analytical, observational, open, prospective study. The study included 99 patients: 13 with microadenoma and 86 with macroadenoma (25 enclosed, 32 extrasellar, 29 invasive). Age, gender, estimated disease duration, body mass index, GH and IGF-I levels, and tumor volume at diagnosis and after 12 months of treatment were measured. Percentage of GH, IGF-I, and tumor size changes from baseline were also analyzed. Tumor changes were scored as absent (+/- 0-25%), mild (+/- 25.1-50%), moderate (+/- 50.1-75%), or notable (75%). Sixty patients (60.6%) received depot octreotide im (20-30 mg every 28 d), and 39 patients (39.4%) received lanreotide im (60-90 mg every 28 d). Basal tumor volume and maximal tumor diameter correlated with age, disease duration, and GH levels. After 12 months, GH levels were controlled (</=2.5 microg/liter) in 57.6%, IGF-I levels in 45.5%, and both in 42.4%. Shrinkage was absent in 22 patients (22.2%), mild in 31 (31.1%), moderate in 30 (30.3%), and notable in 14 patients (14.1%). Two patients (n...Continue Reading

Citations

Mar 7, 2009·Pituitary·Yoel ToledanoIlan Shimon
Dec 29, 2007·Reviews in Endocrine & Metabolic Disorders·Annamaria ColaoGaetano Lombardi
Dec 29, 2007·Reviews in Endocrine & Metabolic Disorders·John D Carmichael, Vivien S Bonert
Jun 18, 2009·Advances in Therapy·F CastinettiT Brue
Jul 25, 2009·Nature Reviews. Endocrinology·Laurence Katznelson
Dec 15, 2006·The New England Journal of Medicine·Shlomo Melmed
Nov 14, 2012·Therapeutic Advances in Endocrinology and Metabolism·Zelija Velija-Asimi
Mar 10, 2010·Journal of Medical Case Reports·Christian WusterRobert Reisch
Nov 7, 2007·European Journal of Endocrinology·Annamaria ColaoGaetano Lombardi
Oct 6, 2012·European Journal of Endocrinology·Josep OriolaManuel Puig-Domingo
Oct 27, 2009·Drugs·Richard A FeeldersAart-Jan van der Lely
Oct 5, 2010·Neurosurgical Focus·Sunil ManjilaWarren R Selman
May 18, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·Amir H Sam, Karim Meeran
Mar 30, 2010·Journal of Endocrinological Investigation·A Colao, G Lombardi
Oct 12, 2010·Journal of Endocrinological Investigation·O Celik, P Kadioglu
Feb 6, 2008·Journal of Endocrinological Investigation·A ColaoUNKNOWN A.L.I.C.E. (Acromegaly primary medical treatment Learning and Improvement with Continuous Medical Education) study group
Sep 16, 2008·Reviews in Endocrine & Metabolic Disorders·Annamaria ColaoGaetano Lombardi
Aug 27, 2009·Biologics : Targets & Therapy·Ferdinand RoelfsemaJohannes A Romijn
Jul 18, 2015·Expert Opinion on Drug Safety·Ludovica F S GrassoAnnamaria Colao
Dec 5, 2008·Expert Opinion on Investigational Drugs·Jens BollerslevJens P Berg
Oct 6, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Michael H Shanik
Oct 29, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Luque-RamírezUNKNOWN Grupo Español del estudio OASIS
Jan 15, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yoshiyasu IwaiKatsunobu Yoshioka
Jan 15, 2008·Molecular and Cellular Endocrinology·Anat Ben-Shlomo, Shlomo Melmed
Mar 29, 2007·Clinical Endocrinology·Annamaria ColaoGaetano Lombardi
Nov 16, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·David R Clemmons
Mar 26, 2011·Expert Opinion on Pharmacotherapy·Annamaria ColaoGaetano Lombardi
Apr 19, 2011·Orvosi hetilap·Gábor László KovácsMiklós Góth
May 27, 2014·Pituitary·E Fernandez-RodriguezI Bernabeu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Pamela U FredaDaniel Rabinowitz
The Journal of Clinical Endocrinology and Metabolism
I M HoldawayGreg D Gamble
© 2021 Meta ULC. All rights reserved