Predictors of Venous Thromboembolism in Patients With Testicular Germ Cell Tumors: A Retrospective Study.

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Hikmat Abdel-RazeqRayan Bater

Abstract

Malignancy, including testicular tumors, significantly increases the risk of venous thromboembolism (VTE). In this study, we search for predictors that may help identify subgroups of patients at higher risk of VTE. Patients with confirmed diagnosis of testicular germ cell tumor and proven VTE were identified. Clinical and pathological features possibly associated with VTE were reviewed. A total of 322 patients, median age (range) 31 (18-76) years were identified. Tumors were mostly non-seminoma (n = 194, 60.2%), node-positive (n = 130, 40.4%) and 58 (18.0%) had metastatic disease at diagnosis. Venous thromboembolism were confirmed in 27 (8.4%) patients; however, rates were significantly higher (P < 0.001) in patients with node-positive (18.5%), metastatic disease (22.4%), and those with high lactate dehydrogenase (LDH) (21.3%). Rates were also significantly higher among those who received multiple lines of chemotherapy (27.5%) compared to those who received one line (13.8%) or none (<1.0%), P < 0.001. Patients with testicular tumors and high tumor burden, including nodal involvement, high LDH or metastatic disease, and those treated with multiple lines of chemotherapy have significantly higher rates of VTE.

References

Nov 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L H Einhorn
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S B SaxmanL H Einhorn
May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N I WeijlS Osanto
Jan 14, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K-P DieckmannUNKNOWN German Testicular Cancer Study Group
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Russell A MooreHani Hassoun
Nov 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sonia SengMatthew D Galsky
Aug 3, 2013·Blood·Jasmijn F TimpSuzanne C Cannegieter
Jun 26, 2014·The New England Journal of Medicine·Jean M Connors
Jul 18, 2014·World Journal of Urology·Manas NigamScott Eggener
Nov 20, 2014·The New England Journal of Medicine·Nasser H Hanna, Lawrence H Einhorn
Nov 9, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marco GizziKarim Fizazi
Feb 12, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hikmat Abdel-RazeqMohammad Ibrahim
Mar 16, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Y WangA J Tafur
Sep 2, 2017·Journal of Thrombosis and Thrombolysis·Hikmat Abdel-Razeq, Asem Mansour
Mar 17, 2018·Blood·Anat Rabinovich, Susan R Kahn
Dec 14, 2018·World Journal of Urology·Pia PaffenholzAxel Heidenreich
Aug 6, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nigel S KeyAnna Falanga
Aug 6, 2019·Seminars in Thrombosis and Hemostasis·Bal Krishan SharmaJoseph S Palumbo
Jan 9, 2020·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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