Prednisolone absorption in coeliac disease

European Journal of Drug Metabolism and Pharmacokinetics
M E PickupC O Record

Abstract

The pharmacokinetic disposition of prednisolone was studied following oral administration (10 mg) to eight patients with untreated coeliac disease of mild or moderate severity, seven coeliac patients on a strict gluten-free diet and ten normal subjects. No significant differences were shown in the peak prednisolone level, the time of the peak level, the area under the concentration versus time plot, the plasma half-life and the 24 h urinary recovery of prednisolone in the three subject groups. There was however considerable variability within each group. It is concluded that the presence of coeliac disease does not significantly alter the absorption or elimination of prednisolone.

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Citations

Sep 29, 2012·Clinical Pharmacokinetics·Troels K BergmannChristine E Staatz
May 17, 2018·The Journal of Pharmacy and Pharmacology·Angela EffingerNikoletta Fotaki
Dec 4, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Tran H TranRobert A Mangione
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