Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting pruritic, erythema, edema, excoriation, and thickening of the skin, and thus leads to significant impairment in the patient's life. The objective of this study is to develop a steroid drug [prednisolone (PS)]-loaded coatable hydrogel for the treatment of AD. PS-loaded hydrogel was composed of PVA entrapped in mildly crosslinked alginate (PS-loaded PVA/ALG hydrogel). The PS concentration to be loaded in the hydrogel that takes AD efficacy without cell necrosis was determined from the cytotoxicity test using human dermal fibroblasts. The in vivo therapeutic effects for AD of the PS-loaded PVA/ALG hydrogel were evaluated using 2, 4-dinitrochlorobenzene (DNCB)-induced AD Balb/c mouse model. The PS-loaded hydrogel has an appropriate viscosity for easy application and provides moisturizing effect on the skin, as well as anti-inflammatory effect by the sustained drug release for effective AD treatment. From the animal study, the PS-loaded PVA/ALG hydrogel showed effective suppressions of various AD symptoms such as ear edema, pruritus, high IgE levels, epidermal swelling, and mast cell infiltration. Our findings suggest that the PS-loaded coatable PVA/ALG hydrogel...Continue Reading
References
Jul 1, 1992·Pharmaceutical Research·S H YukH B Lee
Mar 1, 1997·International Immunology·H MatsudaC Ra
Jul 23, 1997·European Journal of Pharmacology·Y GuoK Maeyama
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·C S Koblenzer
Mar 22, 2002·Journal of the American Academy of Dermatology·Lawrence F EichenfieldMichael Graeber
Jun 27, 2003·European Journal of Pharmacology·Norikazu TakanoMichio Kurachi
Oct 19, 2004·Journal of Dermatological Science·Tetsuo ShioharaYoshiko Mizukawa
Oct 21, 2005·The New England Journal of Medicine·Turk Rhen, John A Cidlowski
Dec 31, 2005·Journal of the American Academy of Dermatology·Ulrich R HenggeMichael J Cork
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Cezmi A AkdisUNKNOWN European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Todd A LevinChristine C Johnson
Apr 27, 2011·Psychiatry Investigation·Tae-Suk KimTae-Youn Jun
Nov 30, 2011·Progress in Polymer Science·Kuen Yong Lee, David J Mooney
Jul 28, 2013·Drug Development and Industrial Pharmacy·Taek Kwan Kwon, Jin-Chul Kim
Dec 19, 2013·International Journal of Pharmaceutical Investigation·Amit Kumar DeArup Mukherjee
Mar 19, 2014·Current Allergy and Asthma Reports·Rachana Agrawal, Judith A Woodfolk
Jun 14, 2014·Current Opinion in Pediatrics·Christine R TotriLawrence F Eichenfield
Aug 30, 2014·PloS One·Heejung KimKi Won Lee
Dec 6, 2014·Clinical and Experimental Dermatology·J Y KimC H Oh
Jan 27, 2015·BMC Complementary and Alternative Medicine·Shiow-Yunn SheuCherng-Jyh Ke
Apr 9, 2015·JAMA Dermatology·Girish C Mohan, Peter A Lio
Apr 15, 2015·Marine Drugs·Na-Jin KangEun-Sook Yoo
Jun 24, 2015·Journal of Dermatological Science·Mira JungJiyoung Kim
Jan 19, 2016·Pediatric Dermatology·Wynnis L TomLee T Zane
Mar 10, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Guilherme T VossEthel A Wilhelm
Mar 31, 2018·Postȩpy dermatologii i alergologii·Jagoda PelcZygmunt Adamski
Apr 21, 2018·Allergy, Asthma & Immunology Research·Myungsoo JunEung Ho Choi
Apr 26, 2018·Drugs in Context·Kam Lun HonTing Fan Leung