Prednisolone versus dexamethasone in croup: a randomised equivalence trial.

Archives of Disease in Childhood
A Sparrow, G C Geelhoed

Abstract

Croup remains a common respiratory problem presenting to emergency departments. A single oral treatment of oral dexamethasone results in improved outcome. Prednisolone has similar pharmacokinetic properties and has a significant advantage in that it is commercially available in liquid preparations. To ascertain whether a single oral dose of prednisolone was equivalent to a single oral dose of dexamethasone (matched for potency) in children with mild to moderate croup. A double blind, randomised, controlled equivalence trial. Tertiary paediatric emergency department. 133 children aged 3 to 142 months presenting with mild to moderate croup. Children received either a single oral dose of dexamethasone 0.15 mg/kg or single oral dose of prednisolone 1 mg/kg. The main outcome measure was unscheduled re-presentation to medical care as determined by telephone follow up at 7 to 10 days. Croup score, adrenaline (epinephrine) use, time spent in the emergency department, and duration of croup and viral symptoms were secondary outcome measures. Children treated with prednisolone were more likely to re-present: 19 of 65 children (29%) reattended medical care compared with 5 of 68 (7%) from the dexamethasone group. The confidence intervals ar...Continue Reading

References

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Citations

Feb 26, 2008·Lancet·Candice L Bjornson, David W Johnson
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