PMID: 6976120Nov 1, 1981Paper

Prednisone-responsive aplastic anemia associated with T-lymphocyte proliferation

American Journal of Hematology
S Bodner, H J Cohen

Abstract

In some cases, bone marrow aplasia has been thought to result from immunologic abnormalities. Our patient had severe transfusion-dependent aplastic anemia, which responded to treatment with prednisone on two occasions. The exacerbations of aplastic anemia were associated with lymphocytic proliferation which on one occasion had the characteristics of T-cell chronic lymphocytic leukemia. Though he had had mild lymphoproliferation for a number of years, he ultimately died with progressive diffuse lymphoid infiltration of the bone marrow and other organs. The simultaneous occurrence of the T-cell lymphoproliferation and aplastic anemia and their simultaneous response to therapy suggests that this may be a clinical example of T-lymphocyte mediated suppression of erythropoiesis.

References

Jan 1, 1978·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·R J Lukes
Jan 6, 1977·The New England Journal of Medicine·R HoffmanL R Wasserman
Dec 30, 1976·The New England Journal of Medicine·D T BaranM R Klemperer
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W A KaganR A Good
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Oct 1, 1970·The Journal of Pediatrics·D K MelhornA J Newman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.