Prednisone withdrawal late after adult liver transplantation reduces diabetes, hypertension, and hypercholesterolemia without causing graft loss

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M D StegallI Kam

Abstract

We prospectively withdrew prednisone in 28 adult patients who had stable graft function more than 2 years after orthotopic liver transplantation (OLTx) and had been on 5 mg/d prednisone for at least 6 months. Prednisone was decreased from 5 mg/d to 2.5 mg/d for 1 month then stopped completely. Cyclosporine monotherapy was maintained at a level of approximately 200 ng/mL (TDX). Nineteen patients had prednisone withdrawn without complications. Four (14.2%) had modest elevations in liver function tests (two biopsy proven mild rejections and two were not biopsied). These four were treated with methylprednisolone boluses and then withdrawal of steroids again. Prednisone was restarted in five patients because of generalized fatigue and body aches (n = 4) and colitis (n = 1). Steroids later were successfully withdrawn in two of these patients. After prednisone withdrawal, three of five insulin-dependent diabetic patients were able to discontinue insulin therapy and their glycosylated hemoglobin levels improved. Four of fourteen hypertensive patients were able to discontinue antihypertensive medicines. Mean serum cholesterol decreased from 222.6 +/- 43.3 to 188.3 +/- 33.3 mg/dL (P < .001). The number of patients with serum cholesterol ...Continue Reading

Citations

Apr 18, 2002·Transplantation Proceedings·R Charco
Aug 15, 2002·Transplantation Proceedings·J FiguerasR Dominguez-Granados
Jun 24, 1998·Transplantation Proceedings·S R MartinF Alvarez
Sep 2, 1998·Transplantation Proceedings·E AtillasoyS Emre
Dec 5, 1998·Transplantation Proceedings·C B RamirezT Kizilisik
Aug 24, 1999·Transplantation Proceedings·S NarumiN L Ascher
Sep 29, 1999·Transplantation Proceedings·M RomeroG Clemente
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·G TisoneC U Casciani
Aug 2, 2012·World Journal of Gastroenterology : WJG·Eric R Kallwitz
Mar 16, 2001·Expert Opinion on Pharmacotherapy·G CiancioJ Miller
Jan 16, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Helem S RibeiroMaria Isabel T D Correia
Jul 4, 2007·Clinics in Liver Disease·Lawrence U Liu, Thomas D Schiano
Aug 15, 2002·Transplantation Proceedings·J AguirrezabalagaM Gómez
May 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R CharcoC Margarit
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L S BelliG Idèo
Mar 1, 2007·Journal of Ultrasound·M RossiP B Berloco
Jun 20, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R T PadburyP McMaster
Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T E TrouillotG T Everson
Jan 16, 2004·Transplantation·David A J NealGraeme J M Alexander
Feb 15, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C ManzarbeitiaS J Munoz
Apr 17, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J F TrotterI Kam
Jun 1, 2000·Clinical Transplantation·R M Jindal, J M Dubernard
Dec 26, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D A Neal, G J Alexander
Nov 2, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A Reuben
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Andrew D BostomRussell H Wiesner
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Davila, E B Keeffe
May 15, 2007·Transplantation·George Mells, James Neuberger
May 22, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C MoenchG Otto
Nov 26, 2008·Nature Clinical Practice. Gastroenterology & Hepatology·Daniel BentenMartina Sterneck
Jan 6, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Jan LerutPierre Gianello
Jul 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B M McGuireUNKNOWN American Society of Transplantation
Dec 2, 2009·Transplantation·Carlos BenítezAlberto Sánchez Fueyo
May 27, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Shireena DesaiSammy Saab
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C E BenítezA Sánchez-Fueyo
Jul 13, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Olaf GuckelbergerPeter Neuhaus
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·V KaulS Munoz
Jul 12, 2002·Drugs·Maria L Raimondo, Andrew K Burroughs
Sep 19, 2014·World Journal of Gastroenterology : WJG·Xiang LanPing Chen
Apr 9, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniel BaronSophie Brouard

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